Investigating pulmonary blood flow during exercise

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical research collaboration aims to explore the prognostic implications of pulmonary hemodynamics during exercise through a large-scale multi-center approach. The study will utilize both retrospective and prospective analyses of hemodynamic data collected from patients undergoing right heart catheterization. By assessing pulmonary blood flow during physical activity, the research seeks to better understand the impact of pulmonary circulation diseases on patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for RHC at rest and exercise
* Written informed consent of participating subjects after being fully briefed (for prospective analysis)

Exclusion Criteria:

* Patients with incomplete hemodynamic data at rest or exercise
* Patients without sufficient follow-up data (information on survival / lung transplantation)
* advanced tumour disease or other diseases with a short life expectancy, except pulmonary vascular diseases
* advanced heart failure with pulmonary arterial wedge pressure (PAWP) \> 18 mmHg at rest
* uncontrolled systemic arterial hypertension (RR values \> 160/100 mmHg at rest)
* FEV1\<50% predicted
* TLC\<60% predicted

Where it's running

• University of Arizona, Banner University Medical Center
  Phoenix, Arizona, United States Recruiting
• University of California, Los Angeles, Lung & Heart-Lung Transplant and Pulmonary Hypertension Programs, David Geffen School of Medicine
  Los Angeles, California, United States Recruiting
• Johns Hopkins Hospital, Advanced HF, MCS, Transplant Cardiology, Baltimore, Maryland, USA
  Baltimore, Maryland, United States Recruiting
• Massachusetts General Hospital, Cardiology Division and Pulmonary Unit
  Boston, Massachusetts, United States Recruiting
• Harvard Medical School, Brigham and Women's Hospital
  Boston, Massachusetts, United States Recruiting
• University of Minnesota Medical School, Division of Cardiology, Department of Medicine, Lillehei Heart Institute Minneapolis, Minnesota, USA
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Study coordinator: Gabor Kovacs, MD
• Email: gabor.kovacs@klinikum-graz.at
• Phone: +43-316-385

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.