Clinical trial Recruiting at 1 site Phase 4 Interventional

Investigating psychiatric and cognitive traits in specific genetic syndromes

Official title: The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome (VCFS), Williams Syndrome (WS)and Fragile X Syndrome Characterization, Treatment and Examining the Connection to Developmental and Molecular Factors

Run by The Chaim Sheba Medical Center · NCT00768820 · Data updated 2026-11-12

This study is testing how certain medications can help improve mental and thinking skills in people with Velocardiofacial Syndrome, Williams Syndrome, and Fragile X Syndrome.

More Fragile X Syndrome trials

Quick facts

PhasePhase 4
Study typeInterventional
SexAll
Enrollment400 (estimated)
SponsorThe Chaim Sheba Medical Center
Academic / other
Locations1 site (Petah Tikva)
StatusRecruiting
StartedMay 2001
Main results expectedAugust 2027
Study endsAugust 2027
Registry record updatedMarch 18, 2026
Trial IDNCT00768820 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals diagnosed with Velocardiofacial Syndrome, Williams Syndrome, or Fragile X Syndrome who have a proven chromosomal deletion.

Probably not a fit

Patients without a confirmed chromosomal deletion or those with other unrelated psychiatric conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the psychiatric and cognitive phenotypes associated with Velocardiofacial Syndrome, Williams Syndrome, and Fragile X Syndrome. It involves administering treatments such as methylphenidate, fluoxetine, and risperidone to assess their effects on these phenotypes. The research will also examine the connections between these traits and developmental as well as molecular factors. By characterizing these conditions, the study seeks to enhance understanding and treatment options for affected individuals.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies for patients with these genetic syndromes.

How similar studies have gone: While there have been studies on the cognitive and psychiatric aspects of these syndromes, this particular approach focusing on treatment effects is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* chromosomal deletion proven by FISH examination

Exclusion Criteria:

Where it's running

  • Schneider Children's Mediac Center of Israel
    Petah Tikva, Israel
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.