Investigating psychiatric and cognitive traits in specific genetic syndromes
Official title: The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome (VCFS), Williams Syndrome (WS)and Fragile X Syndrome Characterization, Treatment and Examining the Connection to Developmental and Molecular Factors
Run by The Chaim Sheba Medical Center · NCT00768820 · Data updated 2026-11-12
This study is testing how certain medications can help improve mental and thinking skills in people with Velocardiofacial Syndrome, Williams Syndrome, and Fragile X Syndrome.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | The Chaim Sheba Medical Center Academic / other |
| Locations | 1 site (Petah Tikva) |
| Status | Recruiting |
| Started | May 2001 |
| Main results expected | August 2027 |
| Study ends | August 2027 |
| Registry record updated | March 18, 2026 |
| Trial ID | NCT00768820 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with Velocardiofacial Syndrome, Williams Syndrome, or Fragile X Syndrome who have a proven chromosomal deletion.
✕Probably not a fit
Patients without a confirmed chromosomal deletion or those with other unrelated psychiatric conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the psychiatric and cognitive phenotypes associated with Velocardiofacial Syndrome, Williams Syndrome, and Fragile X Syndrome. It involves administering treatments such as methylphenidate, fluoxetine, and risperidone to assess their effects on these phenotypes. The research will also examine the connections between these traits and developmental as well as molecular factors. By characterizing these conditions, the study seeks to enhance understanding and treatment options for affected individuals.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with these genetic syndromes.
How similar studies have gone: While there have been studies on the cognitive and psychiatric aspects of these syndromes, this particular approach focusing on treatment effects is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * chromosomal deletion proven by FISH examination Exclusion Criteria:
Where it's running
-
Schneider Children's Mediac Center of Israel
Petah Tikva, Israel Recruiting
Study contacts
- Study coordinator: Doron Gothelf, MD
- Email: gothelf@post.tau.ac.il
- Phone: 972-03-5302663
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.