Investigating proteins related to postoperative delirium in diabetes patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between postoperative delirium (POD) and specific proteins associated with the TGF-β and INS-PI3K-AKT signaling pathways in patients with diabetes. Conducted at two centers, the study involves collecting blood samples from participants before surgery to analyze levels of proteins such as ADNP, MAP6, and PGC-1α using ELISA. The study is designed to be single-blind, meaning that subjects and evaluators are unaware of the specific details of the study to minimize bias.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥65 years
2. History of diabetes ≥2 years and Glycated hemoglobin ≥6.5% or no history of diabetes and normal blood glucose
3. The ASA rating is Class I to III
4. The elderly patients of limited thoracic and abdominal tumor surgery

Exclusion Criteria:

1. Refused to participate
2. Previous history of schizophrenia, epilepsy, Parkinson's disease
3. History of alcohol abuse or drug dependence
4. Patients with ASA grade IV and above
5. Severe visual or hearing impairment, can not cooperate with the completion of cognitive function tests
6. Participants in other clinical trials within the last two months
7. Patients with severe arrhythmia or cardiac dysfunction(EF\<40%)
8. There was a clear history of neurological and psychiatric problems or long-term use of sedatives or antidepressants
9. History of cerebrovascular disease or brain surgery or trauma
10. Severe liver dysfunction (Child-Pugh class C) or severe renal dysfunction (requiring dialysis)

Where it's running

• Zhejiang Cancer Hospital
  Hangzhou, Zhejiang, China Recruiting
• The People's hospital of Qiannan
  Duyun, Guizhou, China Not yet recruiting

Study contacts

• Principal investigator: Kangjie Xie, MD — Zhejiang Cancer Hospital
• Study coordinator: Kangjie Xie, MD
• Email: xiekj@zjcc.org.cn
• Phone: 8613516721870

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.