Investigating postoperative delirium in patients recovering from anesthesia
Analysis of the Incidence and Influencing Factors of Postoperative Delirium in the Post-anesthesia Care Unit: A Multicenter, Observational, Matched Case-control Study
This study is trying to see how common confusion after surgery is in patients waking up from anesthesia and what factors might contribute to it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3320 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Tongji Hospital Academic / other |
| Locations | 2 sites (Harbin, Heilongjiang and 1 other locations) |
| Trial ID | NCT06318364 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the incidence of postoperative delirium (POD) in the post-anesthesia care unit (PACU) and identify factors that influence its occurrence. It employs a multi-center, case-control design with propensity score matching to enhance statistical analysis. Researchers will collect general clinical information, surgical-anesthesia-related data, and blood samples from participants to analyze potential pathophysiological mechanisms associated with POD. The study will categorize subjects into delirium and non-delirium groups for further analysis of risk factors.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who are undergoing surgery and meet the ASA classification I-IV.
Not a fit: Patients with severe central nervous system diseases, psychiatric disorders, or significant cognitive impairment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early screening and intervention strategies for patients at high risk of postoperative delirium.
How similar studies have performed: Other studies have explored postoperative delirium, but this specific approach using propensity score matching is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients voluntarily participating in this study 2. Age ≥18 years old 3. ASA classification I-IV 4. Complete clinical data Exclusion Criteria: 1. ASA classification V and above 2. History of severe central nervous system diseases, psychiatric disorders, cognitive impairment, intellectual disability, or Mini-Mental State Examination (MMSE) score ≤23 3. Patients with communication barriers 4. Patients with missing clinical data 5. Patients with severe complications during PACU observation requiring reintubation, reoperation, or transfer to the intensive care unit for further treatment
Where this trial is running
Harbin, Heilongjiang and 1 other locations
- The First Hospital of Harbin Medical University — Harbin, Heilongjiang, China (Recruiting)
- Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (Recruiting)
Study contacts
- Principal investigator: Qin Zhang — Tongji Medical College, Huazhong University of Science and Technology
- Study coordinator: Xiao Ran
- Email: ranxiao1001@tjh.tjmu.edu.cn
- Phone: 15926207366
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.