Investigating plant-based protein effects on health compared to animal protein
Functional and Nutritional Plant-based Mixed Protein Study (FuN Protein Study)
NA · Singapore Institute of Food and Biotechnology Innovation · NCT06421194
This study tests whether eating meals with plant-based proteins is better for feeling full and overall health compared to meals with animal proteins, especially for people in Asia.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 28 (estimated) |
| Ages | 21 Years to 45 Years |
| Sex | Male |
| Sponsor | Singapore Institute of Food and Biotechnology Innovation (other gov) |
| Locations | 1 site (Singapore) |
| Trial ID | NCT06421194 on ClinicalTrials.gov |
What this trial studies
This study examines the impact of optimized plant protein mixtures versus animal protein on satiety, protein metabolism, and overall metabolic health. Conducted by the Singapore Institute of Food and Biotechnology Innovation, it focuses on enhancing the nutritional quality of plant-based diets, particularly for the Asian demographic. Participants will consume various meals containing either plant-based or animal-based proteins to evaluate their effects on postprandial metabolism. The study aims to address concerns regarding the amino acid profiles of plant proteins and promote healthier dietary choices.
Who should consider this trial
Good fit: Ideal candidates are healthy Chinese males aged 21 to 45 with a BMI between 18.5 and 27.5.
Not a fit: Patients with dietary restrictions, allergies to common food ingredients, or those following special diets like vegetarianism or veganism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved metabolic health outcomes for individuals adopting plant-based diets.
How similar studies have performed: Other studies have shown promising results in optimizing plant-based diets, but this specific approach is novel in its focus on Asian-centric food products.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male * Chinese ethnicity * Age between 21 to 45 years * Body Mass Index (BMI) between 18.5 to 27.5 kg/m2 * English-literate Exclusion criteria: * Smoking * Having allergies or intolerances to any common food ingredients including eggs, fish, milk, peanuts, and tree nuts, shellfish, soya, wheat, pea, gluten, cereal, fruits, dairy products, meat, vegetable, sugar and sweetener, natural food colourings or flavourings, etc. * Following special diets or having intentional dietary restrictions (e.g., vegetarians/vegans) * Having a dislike towards plant-based or chicken-based foods * Not willing to adhere to diet modification as in the study's instructions * Not willing to stop any strenuous activity during or within 24 hours of test days * Having glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) * Having alcohol consumption on \> 4 days per week with ≥ 6 alcoholic drinks per week * Having sustained elevation of blood pressure (\>160/95 mm Hg) * HbA1c reading ≥ 6.5% (raised non-fasted/random HbA1c as defined by WHO/ IDF) * Having previously undergone any gastrointestinal surgery or having history of gastrointestinal disorders * Having a history of heart, liver, kidney, blood disorders (e.g., thalassemia) or thyroid dysfunctions * Diabetic * Having history of tuberculosis, HIV, Hepatitis B or Hepatitis C infections * Having any prescription medication or any other alternative medicines or supplements (amino acids supplements, e.g. L-carnitine, glutamine and arginine) which may interfere with study measurements in the opinion of the study investigators * Having antibiotics or suffering from diarrhoea within the last 4 weeks * Having donated blood within 4 weeks of study participation * Having poor veins or having history of severe vasovagal syncope (blackouts or fainting) from blood draws * Employees of the SIFBI (Singapore Institute of Food and Biotechnology Innovation).
Where this trial is running
Singapore
- Clinical Nutrition Research Centre — Singapore, Singapore (RECRUITING)
Study contacts
- Principal investigator: Melvin Leow, Professor — Singapore Institute of Food and Biotechnology Innovation (SIFBI), A*STAR
- Study coordinator: Melvin Leow, Professor
- Email: melvin_leow@sifbi.a-star.edu.sg
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Nutrition, Healthy, plant-based protein, Asian, diet, health outcomes, animal-based protein