Investigating ovarian tissue cryopreservation in girls with Turner syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to explore the effectiveness of cryopreserving ovarian tissue in girls diagnosed with Turner syndrome to enhance their fertility potential. Participants aged 2 to 18 will undergo laparoscopic surgery to remove one ovary for cryopreservation, with the goal of later autotransplantation to facilitate pregnancy. The study will also assess the relationship between hormone monitoring and menopause onset, as well as investigate genetic factors contributing to ovarian failure in Turner syndrome. By addressing these questions, the trial seeks to improve reproductive outcomes for women with Turner syndrome.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 45,X karyotype or other Turner variant karyotypes (45,X/46,XX mosaicism, ring X mosaicism, isochromosome X)
* Age 2-17 years old
* Ability to participate in a physical examination including a cardiac examination.
* Signed consent from both parents.

Exclusion Criteria:

* Severe cardiac disease which inhibits safe surgery and pregnancy.
* Karyotype with Y chromosome material
* Mental retardation

Where it's running

• Mette Viuff
  Aarhus, Denmark Recruiting

Study contacts

• Study coordinator: Mette H Viuff, MD PhD
• Email: metteviuff@clin.au.dk
• Phone: +45 23705085

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Bleeding patterns with sequential versus continuous progesterone in adolescents with Turner syndrome

  This study will test whether taking progesterone continuously or in a sequential (monthly) schedule changes bleeding patterns in adolescents with Turner syndrome who are on estrogen replacement therapy.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.