Investigating organ damage and immune changes in sepsis
Cell-free DNA Epigenomics to Track the Dynamics of Organ Damage and Immune Exhaustion During Sepsis
This study is trying to see if new blood tests can help find signs of organ damage and immune changes in people with sepsis to improve their care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT06817408 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the dynamics of organ damage and immune exhaustion in patients with sepsis using liquid biopsy next-generation sequencing (NGS). By employing advanced analytical methods, the study seeks to derive a signature matrix that identifies novel biomarkers associated with sepsis. The researchers will analyze data from a specified number of patients to determine the sensitivity of detecting cell-free nucleic acids, which may reflect disease severity. The study is designed to enhance understanding of sepsis and improve patient outcomes through better biomarker identification.
Who should consider this trial
Good fit: Ideal candidates for this study are patients who have developed a shocked state due to sepsis, indicated by hypotension or elevated lactate levels.
Not a fit: Patients under 18 years of age, pregnant women, and nursing women will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the identification of new biomarkers that improve the diagnosis and management of sepsis.
How similar studies have performed: Other studies have shown promise in using liquid biopsy approaches for biomarker discovery, suggesting potential success for this novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Patients who've developed a shocked state (Hypotension or Lactate grade \>4) or Clinical Concern Exclusion Criteria: * \<18 years of age * Pregnant Women * Nursing women
Where this trial is running
Rochester, Minnesota
- Mayo Clinic Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Aadel A Chaudhuri, M.D., Ph.D. — Mayo Clinic
- Study coordinator: Derek E Vanmeter
- Email: Vanmeter.Derek@mayo.edu
- Phone: 507-255-4732
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.