Investigating NFL Levels in Patients After Cardiac Arrest
Dynamics of Light Chain of NFL as a Predictor Factor of Neurological Outcome in Patients With Out of Hospital Cardiac Arrest
This study is testing if measuring a specific protein in the blood can help doctors understand how well patients recover after being resuscitated from a cardiac arrest.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Medical Centre Maribor Academic / other |
| Locations | 1 site (Maribor) |
| Trial ID | NCT05218278 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the pharmacodynamics of neurofilament light chain (NFL) in patients who have experienced out-of-hospital cardiac arrest and have been successfully resuscitated. It will measure serum levels of NFL at various time points after ICU admission to assess differences between patients with favorable and non-favorable neurological outcomes. By analyzing these levels, the study seeks to identify potential biomarkers that could predict neurological recovery in this patient population.
Who should consider this trial
Good fit: Ideal candidates for this study are adults who have experienced out-of-hospital cardiac arrest and have been successfully resuscitated and admitted to the ICU.
Not a fit: Patients who have experienced cardiac arrest due to trauma, drowning, or electrocution, or those under 18 years of age may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new biomarker for predicting neurological outcomes in patients after cardiac arrest.
How similar studies have performed: While the specific approach of measuring NFL levels in this context may be novel, similar studies have shown promise in using biomarkers to predict neurological outcomes after cardiac events.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * out-of-hospital cardiac arrest successfully resuscitated and admitted to the ICU Exclusion Criteria: * trauma, drowning, electrocution, less than 18 years of age,
Where this trial is running
Maribor
- University medical center Maribor — Maribor, Slovenia (Recruiting)
Study contacts
- Principal investigator: Matej Strnad, MD, PhD — University medical cenetr Maribor
- Study coordinator: Matej Strnad, MD, PhD
- Email: strnad.matej78@gmail.com
- Phone: +38651225448
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.