Investigating muscle oxygenation in rheumatoid arthritis patients

Investigation of Respiratory Muscle Strength, Respiratory Muscle Endurance and Muscle Oxygenation in Patients With Rheumatoid Arthritis

This study is testing how well the muscles of people with rheumatoid arthritis work compared to healthy individuals to see how it affects their ability to exercise and stay active.

Quick facts

• Study type: Observational
• Enrollment: 68 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: Kirsehir Ahi Evran Universitesi (other)
• Locations: 1 site (Kırşehir, Merkez)
• Trial ID: NCT06769386 on ClinicalTrials.gov

What this trial studies

This study aims to explore respiratory muscle strength, endurance, and muscle oxygenation in patients with rheumatoid arthritis compared to healthy individuals. It focuses on understanding how these factors affect exercise capacity and overall physical function in RA patients, who often experience pain and fatigue that limit their activity levels. By assessing both upper and lower extremity exercise capacity, the study seeks to uncover the physiological reasons behind muscle dysfunction in rheumatoid arthritis. The findings could provide insights into the impact of RA on physical health and inform future interventions.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18-65 diagnosed with rheumatoid arthritis who are willing to participate.

Not a fit: Patients with serious cardiopulmonary, neurological, or orthopedic conditions, or those who have recently engaged in structured exercise programs, may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance understanding of muscle function in rheumatoid arthritis, leading to improved management strategies and quality of life for patients.

How similar studies have performed: While the specific focus on muscle oxygenation in rheumatoid arthritis may be novel, similar studies have shown that understanding exercise capacity and muscle function can lead to significant improvements in patient care.

Eligibility criteria

Rheumatoid Arthritis Group

Inclusion Criteria:

* Patients diagnosed with rheumatoid arthritis,
* The ages of 18-65 years,
* Volunteer to participate in the study will be included in the study.

Exclusion Criteria:

* Serious cardiopulmonary, neurological, neuromuscular, orthopedic and other systemic diseases or other diseases affecting physical functions,
* Participated in a planned exercise program in the last three months,
* Cognitive impairment that will cause difficulty in understanding and following exercise test instructions,
* Contraindications to exercise testing or exercise training according to the American Sports Medicine Association will not be included in the study.

Control Group

Inclusion Criteria:

* The ages of 18-65 years,
* Volunteer to participate in the study will be included in the study.

Exclusion Criteria:

* Diagnosed chronic or systemic disease,
* Regular exercise (physical activity) 3 days a week, 150 minutes/week of moderate intensity
* Smoking 10 packs x years or more,
* Pneumonia or any acute infection,
* Healthy individuals with any psychiatric disorder will not be included in the study.

Where this trial is running

Kırşehir, Merkez

• Kırşehir Ahi Evran University, Physical Therapy and Rehabilitation Center, Cardiopulmonary Unit — Kırşehir, Merkez, Turkey (Türkiye) (RECRUITING)

Study contacts

• Principal investigator: Başak KAVALCI KOL, PhD — Kirsehir Ahi Evran Universitesi
• Study coordinator: Başak KAVALCI KOL, PhD

Conditions: Rheumatoid Arthritis, exercise capacity, muscle oxygenation, rheumatoid arthritis