Investigating miRNA in Follicular Fluid During Oocyte Maturation
Official title: Investigation of Follicular Fluid Exosome miRNA in Young and Aged Women During Oocyte Maturation
Run by Chinese University of Hong Kong · NCT04382872 · Data updated 2026-11-12
This study is testing how certain tiny molecules in the fluid around eggs might affect their development and quality in young and older women who are preparing for fertility treatments like IVF.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 45 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | April 30, 2021 |
| Main results expected | April 30, 2026 |
| Study ends | April 30, 2026 |
| Registry record updated | August 13, 2025 |
| Trial ID | NCT04382872 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 20 to 45 with a BMI between 19 and 35 who are planning to undergo IVF and ICSI.
✕Probably not a fit
Patients who are pregnant, have a BMI over 35, or have specific reproductive health issues such as endometriosis or chromosomal abnormalities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the role of microRNA (miRNA) in follicular fluid exosomes during the maturation of oocytes in both young and aged women. It focuses on understanding how these miRNAs relate to the developmental competence of oocytes, particularly in the context of age-related declines in fertility. By analyzing the hormonal and paracrine interactions within the ovarian environment, the study seeks to uncover the underlying mechanisms affecting oocyte quality and maturation. Participants will include women aged 20 to 45 who are planning to undergo in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).
Why it matters
Potential benefit: If successful, this study could enhance understanding of oocyte maturation and improve fertility treatments for women, particularly those of advanced reproductive age.
How similar studies have gone: While the specific approach of analyzing miRNA in follicular fluid exosomes is relatively novel, similar studies have indicated potential insights into oocyte quality and maturation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Women aged 20 to 45; 2. BMI \> 19 \& \< 35; 3. Women who is planning to perform invitro fertilization (IVF) together with intracytoplasmic sperm injection (ICSI) for their fertility problems Exclusion Criteria: 1. Positive pregnancy test before taking study medications; 2. Women with BMI\>35 kg/m2; 3. Women with known chromosomal translocation, recurrent abortions or those carrying Fragile X; 4. Women with endometriosis
Where it's running
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The Chinese University of Hong Kong
Hong Kong, Hong Kong Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Dual Trigger vs HCG Trigger for Final Maturation in Normal Responders
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.