Investigating microparticle levels in packed red blood cells
Investigating Microparticle Levels In Filtered Packed Red Blood Cell Units
This study is testing how the tiny particles in stored red blood cells might affect the success of blood transfusions for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut) |
| Trial ID | NCT06428747 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the composition of packed red blood cells (pRBCs) and how their microparticle levels may affect transfusion efficacy. It aims to analyze microparticles produced during the storage of pRBCs, which can influence patient outcomes due to their biological effects. The study will utilize flow cytometry to detect and characterize these microparticles, providing insights into their role in coagulation disorders associated with transfusions. By understanding these factors, the study seeks to improve the safety and effectiveness of blood transfusions.
Who should consider this trial
Good fit: Ideal candidates for this study are blood donors who meet the criteria set by the Egyptian National Transfusion Services.
Not a fit: Patients who do not meet the eligibility criteria or have reactive serology will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the safety and efficacy of blood transfusions, reducing adverse effects for patients.
How similar studies have performed: While the investigation of microparticles in blood products is an emerging field, this specific approach to analyzing pRBCs has not been widely tested, making it a novel exploration.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Donors who met criteria of Egyptian National Transfusion Services. * Serological assays for all blood donors (HBsAgs, HCV antibodies, HIV Ag/Ab and Syphilis antibodies) on Architect i 2000 SR or Centaur XPT (chemoluminescence). Exclusion Criteria: * Donors who not met criteria of Egyptian National Transfusion Services. * Reactive serology.
Where this trial is running
Asyut
- Assiut university — Asyut, Egypt (Recruiting)
Study contacts
- Study coordinator: Doha Sholkamy, phD
- Email: yfahmy330@gmail.com
- Phone: 01097858588
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.