Investigating markers in children with sudden-onset neuropsychiatric symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the neurologic, immunologic, and rheumatologic markers in children diagnosed with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). The study will recruit 500 children aged 1-18 who have experienced a recent onset of PANS symptoms, and these participants will be compared to 100 healthy age- and gender-matched controls. By examining various biological components, the research seeks to uncover underlying mechanisms associated with PANS, which may be triggered by infections or inflammation. The findings could provide insights into the condition and inform future treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children with PANS

  1. Age 1-18 at onset of PANS
  2. Diagnosis of PANS: abrupt onset of OCD or food restriction, and at least two of the following associated symptoms: frequent urination, worsening handwriting/cognition, inattention, anorexia, separation anxiety, oppositionality, irritability/rage outbursts, and emotional lability.
  3. Patients must live within 90 miles of Stanford University and have a new onset of PANS illness
  4. Patients must have an established pediatrician within 90 miles of Stanford University for 3 years.
* Healthy Controls

  1. Age 4-18
  2. No psychiatric diagnosis

Exclusion Criteria:

* Any neuropsychiatric illness that may obscure the clear diagnosis of PANS

Where it's running

• Stanford University
  Palo Alto, California, United States Recruiting

Study contacts

• Study coordinator: Joanne Cheung
• Email: pansresearch@stanford.edu

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Biomarkers for PANS: Diagnosing and Tracking Pediatric Neuropsychiatric Symptoms

  This study tests a panel of biomarkers to help diagnose PANS in children and see if they reflect disease course and response to treatment.

  Recruiting University of Cagliari · Cagliari, Cagliari and 4 other locations · NCT07718958

• Study on Pediatric Autoimmune Neuropsychiatric Disorders Linked to Streptococcus

  This study is looking at how common certain neuropsychiatric disorders are in children aged 3-17 and how they might be linked to a specific type of bacteria called Group A streptococcus.

  Recruiting at 2 sites University of Wisconsin, Madison · Lebanon, New Hampshire and 1 other locations · NCT06811935

• Evaluating patterns in neurodevelopmental disorders

  This study is trying to find common signs and causes of neurodevelopmental disorders like Autism and Down Syndrome to help with earlier diagnosis and better outcomes for those affected.

  Recruiting Rossignol Medical Center · Phoenix, Arizona · NCT06213090

• A platform for collecting health data on ME/CFS and Long Covid

  This study is trying to collect health information from adults with ME/CFS and Long Covid to help researchers better understand these conditions and improve future treatments.

  Recruiting Brain Inflammation Collaborative · Delafield, Wisconsin · NCT04806620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.