Investigating markers in children with sudden-onset neuropsychiatric symptoms
Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS
This study is testing if certain biological markers in children with sudden neuropsychiatric symptoms can help us understand Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 4 Years to 18 Years |
| Sex | All |
| Sponsor | Stanford University Academic / other |
| Locations | 1 site (Palo Alto, California) |
| Trial ID | NCT02889016 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the neurologic, immunologic, and rheumatologic markers in children diagnosed with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). The study will recruit 500 children aged 1-18 who have experienced a recent onset of PANS symptoms, and these participants will be compared to 100 healthy age- and gender-matched controls. By examining various biological components, the research seeks to uncover underlying mechanisms associated with PANS, which may be triggered by infections or inflammation. The findings could provide insights into the condition and inform future treatment strategies.
Who should consider this trial
Good fit: Ideal candidates are children aged 1-18 who have recently been diagnosed with PANS and live within 90 miles of Stanford University.
Not a fit: Patients with other neuropsychiatric illnesses that could complicate the diagnosis of PANS may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of PANS and improve diagnostic and treatment approaches for affected children.
How similar studies have performed: While this study explores a specific aspect of PANS, similar studies have shown promise in understanding autoimmune and neuropsychiatric disorders, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children with PANS 1. Age 1-18 at onset of PANS 2. Diagnosis of PANS: abrupt onset of OCD or food restriction, and at least two of the following associated symptoms: frequent urination, worsening handwriting/cognition, inattention, anorexia, separation anxiety, oppositionality, irritability/rage outbursts, and emotional lability. 3. Patients must live within 90 miles of Stanford University and have a new onset of PANS illness 4. Patients must have an established pediatrician within 90 miles of Stanford University for 3 years. * Healthy Controls 1. Age 4-18 2. No psychiatric diagnosis Exclusion Criteria: * Any neuropsychiatric illness that may obscure the clear diagnosis of PANS
Where this trial is running
Palo Alto, California
- Stanford University — Palo Alto, California, United States (Recruiting)
Study contacts
- Study coordinator: Joanne Cheung
- Email: pansresearch@stanford.edu
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.