Investigating lung blood vessel issues in long-COVID patients with breathing difficulties

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify pulmonary vascular disease as a potential cause of persistent exertional dyspnea in patients who have recovered from COVID-19. It will differentiate pulmonary vascular dysfunction from other causes of dyspnea, such as muscular or psychological factors, by examining ventilation-perfusion mismatch and exercise-induced pulmonary hypertension. Patients will be evaluated in outpatient clinics specializing in pneumology and infectious diseases, focusing on those with a confirmed COVID-19 diagnosis between 3 to 18 months prior to their presentation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years, patients with a suspected diagnosis of post/long-COVID-19 syndrome who present to our pneumology or infectious disease outpatient clinic or corresponding ward from the start of the study and whose SARS-CoV-2 infection was diagnosed at least 3 and not longer than 18 months prior to presentation
* Patients at least 3 and not longer than 18 months after a SARS-CoV-2 infection without post/long-COVID-19 syndrome who present to our post-infection outpatient clinic for follow-up

Exclusion Criteria:

* Patients who refuse to participate in the study
* Severe underlying chronic pulmonary, cardiac, or systemic disease (e.g., Chronic obstructive pulmonary disease (COPD), severe heart failure, neuromuscular disease) that was diagnosed prior to acute COVID-19 disease and whose progression appears likely as the cause of dyspnea
* Other non pneumologic causes of dyspnea (e.g., hemoglobin \< 100 g/L)
* Unstable or acute disease (e.g., acute infection, acute renal failure, acute coronary syndrome)
* Inability to perform spiroergometry, including transient orthopedic problems, contraindications to central venous and arterial catheter placement (e.g., severe bleeding tendency).

Where it's running

• Natascha Sommer
  Giessen, Germany Recruiting

Study contacts

• Principal investigator: Natascha Sommer, PD — Cardiopulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC)
• Study coordinator: Natascha Sommer, PD
• Email: Natascha.Sommer@innere.med.uni-giessen.de
• Phone: +0049-(0641)985 56742

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.