Investigating long-term effects of COVID-19 through imaging and blood samples
Official title: Specific Markers of Covid-long Syndrome: Identifying the Mechanisms Involved With a View to Defining Diagnostic Criteria
Run by Centre Hospitalier Universitaire de Nice · NCT06528171 · Data updated 2026-11-12
This study is trying to find out how COVID-19 affects people in the long run by looking at brain scans and blood samples from those with ongoing symptoms and those who have fully recovered.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Status | Recruiting |
| Started | December 6, 2024 |
| Main results expected | June 2028 |
| Study ends | June 2028 |
| Registry record updated | June 22, 2026 |
| Trial ID | NCT06528171 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals who have experienced long-term symptoms following COVID-19 infection, as well as those who have fully recovered without persistent symptoms.
✕Probably not a fit
Patients with a history of chronic fatigue syndrome or those who required intensive care during their acute COVID-19 infection may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to better understand the long-term effects of COVID-19, known as COVID long-haul syndrome, by identifying specific biomarkers and developing diagnostic tools. It will recruit 120 participants, including 60 patients experiencing long-term symptoms and 60 controls who have recovered without persistent symptoms. The study will utilize brain MRI and blood samples to gather data for model learning and validation phases. The goal is to establish objective criteria for diagnosing and monitoring the evolution of COVID long-haul syndrome.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic tools and better management strategies for patients suffering from long-term COVID-19 symptoms.
How similar studies have gone: Other studies have explored the long-term effects of COVID-19, but this approach focusing on specific biomarkers and imaging is innovative and may provide new insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
FOR CL+ PATIENTS Inclusion Criteria: * Case definition in line with WHO Delphi process Exclusion Criteria: * History of chronic fatigue syndrome diagnosed before or after Covid. * History of progressive psychiatric pathology. * History of acute Covid requiring admission to intensive care and mechanical ventilation. * No social security affiliation. FOR CONTROL (CL-) Inclusion Criteria: * History of acute COVID-19, mild, moderate or severe (episode at least 3 months at the time of inclusion). * Absence of persistent symptoms more than 3 months after first Covid symptoms (or mild not affecting daily activities). Exclusion Criteria: * History of progressive psychiatric pathology. * History of acute Covid requiring admission to intensive care and mechanical ventilation. * No social security affiliation. * Pregnant or breast-feeding.
Where it's running
-
CHU de NICE
Nice, France Recruiting
Study contacts
- Study coordinator: Michel CARLES, PhD
- Email: carles.m@chu-nice.fr
- Phone: 04 92 03 55 15
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.