Investigating long non-coding RNAs as diagnostic markers in pediatric T-cell leukemia
Long Non-coding RNAs and Their Role on Epigenome as Diagnostic Markers in Childhood
IRCCS SYNLAB SDN · NCT06334835
This study is trying to find specific markers in the blood of children with T-cell leukemia to help doctors diagnose and understand the disease better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 1 Year to 18 Years |
| Sex | All |
| Sponsor | IRCCS SYNLAB SDN (other) |
| Locations | 1 site (Naples) |
| Trial ID | NCT06334835 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify specific long non-coding RNAs (lncRNAs) that can serve as diagnostic and prognostic biomarkers for childhood acute lymphoblastic leukemia of T cells (T-ALL). The research will compare lncRNA expression levels in T-ALL patients with those in healthy subjects and naive T-lymphocytes. By analyzing biological samples collected from pediatric patients, the study seeks to understand the role of lncRNAs in chromatin reorganization and transcriptional regulation related to T-ALL progression. The findings could lead to improved diagnostic tools for this rare cancer.
Who should consider this trial
Good fit: Ideal candidates for this study are pediatric patients aged 1-18 years diagnosed with T-ALL.
Not a fit: Patients outside the age range of 1-18 years or those who do not have a diagnosis of T-ALL will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide new diagnostic and prognostic tools for pediatric patients with T-ALL, potentially improving treatment outcomes.
How similar studies have performed: While the role of lncRNAs in cancer is an emerging field, this specific approach to T-ALL using lncRNAs as biomarkers is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a diagnosis of T-ALL 1-18 years aged of both sexes; * Presence of leukemic cells in peripheral blood of recruited patients. Exclusion Criteria: * Patients who refuse to participate in the study; * Patients not falling in the age group mentioned above
Where this trial is running
Naples
- Irccs Synlab Sdn — Naples, Italy (RECRUITING)
Study contacts
- Principal investigator: Giovanni Smaldone, PhD — IRCCS SYNLAB SDN
- Study coordinator: Laura Pierri, Master
- Email: laura.pierri@synlab.it
- Phone: 0812408260
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Lymphoblastic Leukemia, Pediatric, Lymphocytes, Lymphocyte function, Differentiation of B lymphocytes, Differentiation of T lymphocytes, ALL, CLL, MLL