Investigating lithium clearance in patients with acute kidney injury
Endogenous Lithium Clearance in Acute Kidney Injury
This study is testing how well the kidneys clear lithium in critically ill patients with acute kidney injury to see if their ability to process the drug is affected.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital of North Norway Academic / other |
| Locations | 1 site (Tromsø, Troms) |
| Trial ID | NCT05982340 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the endogenous clearance of lithium in critically ill patients, particularly those diagnosed with acute kidney injury (AKI) due to sepsis. The study will involve collecting blood and urine samples from 30 participants, including 10 ICU patients with AKI, 10 patients without AKI, and 10 healthy controls. By measuring renal clearance of creatinine and lithium at multiple time points throughout the day, the researchers hope to determine if lithium reabsorption is impaired in the early stages of critical illness.
Who should consider this trial
Good fit: Ideal candidates include ICU patients diagnosed with acute kidney injury, patients without AKI, and healthy controls.
Not a fit: Patients with chronic kidney disease or those not critically ill may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of kidney function in critically ill patients and improve management strategies for acute kidney injury.
How similar studies have performed: While the approach of using lithium clearance to assess kidney function is established, this specific application in critically ill patients with AKI is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ICU patients diagnosed with AKI, without AKI and healthy controls Exclusion Criteria: -
Where this trial is running
Tromsø, Troms
- University Hospital of North Norway — Tromsø, Troms, Norway (Recruiting)
Study contacts
- Principal investigator: Lars MG Ytrebø, MD PhD — University Hospital of North Norway
- Study coordinator: Lars Marius Ytrebø
- Email: lars.marius.ytrebo@unn.no
- Phone: 90788058
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.