Investigating jaw bone issues in patients on antiresorptive drugs
Official title: Medication Related Osteonecrosis of the Jaws (MRONJ) in a Cohort of Patients Treated by Antiresorptive Drugs: a Cohort Prospective Study
Run by Catholic University of the Sacred Heart · NCT06457776 · Data updated 2026-11-12
This study is trying to see how often jaw bone problems happen in cancer patients taking certain medications to help with bone issues.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 126 (estimated) |
| Sponsor | Catholic University of the Sacred Heart Academic / other |
| Drugs / interventions | denosumab, radiation |
| Locations | 1 site (Roma) |
| Status | Recruiting |
| Started | January 1, 2021 |
| Main results expected | January 1, 2026 |
| Study ends | January 1, 2028 |
| Registry record updated | June 20, 2024 |
| Trial ID | NCT06457776 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients who have been prescribed antiresorptive drugs for oncohematologic reasons.
✕Probably not a fit
Patients who have previously undergone head and neck radiotherapy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the incidence of Medication Related Osteonecrosis of the Jaws (MRONJ) in patients receiving antiresorptive drugs for oncohematologic conditions over a five-year period. It will also compare the incidence of MRONJ among different antiresorptive medications and identify both systemic and local risk factors associated with this condition. The study focuses on patients who are prescribed these drugs to manage skeletal complications related to cancer. By following these patients, researchers hope to gather valuable data on the safety and risks of antiresorptive therapies.
Why it matters
Potential benefit: If successful, this study could enhance understanding of MRONJ and improve management strategies for patients receiving antiresorptive therapy.
How similar studies have gone: Other studies have indicated varying success in understanding MRONJ, but this specific approach focusing on antiresorptive drugs in oncohematologic patients is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with specific prescription to initiate therapy with antiresorptive drugs Exclusion Criteria: * Previous Head and Neck Radiotherapy
Where it's running
-
Cosimo Rupe
Roma, Italy Recruiting
Study contacts
- Study coordinator: Carlo Lajolo, Prof.
- Email: carlo.lajolo@unicatt.it
- Phone: 3356078354
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.