Investigating inflammation's role in postoperative atrial fibrillation after heart surgery
Inflammation and Postoperative Atrial Fibrillation in Cardiac Surgery
This study looks at how inflammation might affect the heart rhythm in patients after heart surgery to see if certain genes are linked to developing atrial fibrillation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Odense University Hospital Academic / other |
| Locations | 1 site (Odense) |
| Trial ID | NCT06475547 on ClinicalTrials.gov |
What this trial studies
This observational study examines the relationship between inflammation and postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery. It focuses on the role of epicardial fat, which secretes pro-inflammatory cytokines, and how its gene expression can be profiled using RNA sequencing. By comparing patients who develop POAF with those who do not, the study aims to identify key genes associated with inflammation and atrial fibrillation. The findings could enhance understanding of the mechanisms behind POAF and potentially guide future interventions.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who are undergoing cardiac surgery.
Not a fit: Patients who are in poor health or require reoperation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing postoperative atrial fibrillation, reducing complications and healthcare costs for patients.
How similar studies have performed: While the specific approach of using RNA sequencing in this context may be novel, studies have shown that inflammation plays a significant role in atrial fibrillation, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 * Informed consent Exclusion Criteria: * Incompetent individuals * General poor health condition at the time of inclusion * Reoperation
Where this trial is running
Odense
- Odense University Hospital, Cardiac Surgery Department — Odense, Denmark (Recruiting)
Study contacts
- Principal investigator: Lytfi Krasniqi, MD — Odense University Hospital
- Study coordinator: Lytfi Krasniqi, MD
- Email: Lytfi.Krasniqi@rsyd.dk
- Phone: 65412404
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.