Investigating inflammation in non-diabetic patients with Dunnigan lipodystrophy
Impact of Lipodystrophy on the Inflammatory State of Non-diabetic Dunnigan Reunion Island Subjects
This study is trying to see how inflammation levels in adults with Dunnigan lipodystrophy compare to those without the condition.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de la Réunion Academic / other |
| Locations | 1 site (Saint-Pierre) |
| Trial ID | NCT06107439 on ClinicalTrials.gov |
What this trial studies
This study examines the inflammatory profile of adult patients with partial Dunnigan lipodystrophy, focusing on the levels of pro-inflammatory biomarkers compared to control individuals. It aims to account for confounding factors such as smoking and chronic inflammatory diseases that may affect the results. Participants will undergo blood and urine sampling to assess their inflammatory status. The study seeks to provide a clearer understanding of the inflammatory state in these patients, which has been under-researched.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with a confirmed diagnosis of partial Dunnigan lipodystrophy.
Not a fit: Patients with diabetes, those under 18, or individuals with severe health impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of inflammation in patients with Dunnigan lipodystrophy.
How similar studies have performed: While there is limited data on Dunnigan lipodystrophy, similar studies on inflammatory profiles in other conditions have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult subject (\>18 years old) affected by partial Dunnigan lipodystrophy in the homozygous or heterozygous state (genetic search for the positive mutation carried out before inclusion in the study). * Person affiliated to or beneficiary of a social security scheme. * Free, informed and written consent signed by the participant and the investigator. Exclusion Criteria: * - Minor * Persons placed under judicial protection, person participating in another research including a period of exclusion still in progress, severely impaired physical and/or psychological health, which, according to the investigator, may affect the participant's compliance with the study * Previous known diabetes * Pregnant woman * Woman who gave birth less than 6 months ago * Breastfeeding in progress * Participation in other research that may have an impact on the evaluation of the main judgment criteria * Hemoglobin b level \< 7 mg/dl or \< 9-10 mg/dl for patients with cardiovascular or respiratory pathology. * Proven inflammatory pathologies * Anti-inflammatory treatment: taking corticosteroids in the last 3 months. * Active smoking
Where this trial is running
Saint-Pierre
- CHU La Réunion DRCI — Saint-Pierre, Réunion (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.