Investigating inflammation in children with obstructive sleep apnea
Mucosal Inflammation in Children With OSA - Potential Biomarkers of OSA Complications
Chinese University of Hong Kong · NCT06452979
This study is trying to see if inflammation in the noses of children with obstructive sleep apnea is linked to their blood pressure and overall health compared to kids without the condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 110 (estimated) |
| Ages | 6 Years to 11 Years |
| Sex | All |
| Sponsor | Chinese University of Hong Kong (other) |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT06452979 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the variability of clinical phenotypes in childhood obstructive sleep apnea (OSA) by evaluating inflammatory biomarkers in nasal epithelial lining fluid (NELF) from children with OSA compared to non-OSA controls. The study will assess the relationship between these biomarkers and ambulatory blood pressure outcomes in affected children. By using a prospective case-control design, the research seeks to uncover potential links between upper airway inflammation and systemic health issues in this population.
Who should consider this trial
Good fit: Ideal candidates for this study are non-obese children aged 6-11 years old diagnosed with obstructive sleep apnea.
Not a fit: Patients with previous upper airway surgery, obesity, or other specified health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better identification of children at risk for complications related to obstructive sleep apnea.
How similar studies have performed: While the specific approach of using NELF biomarkers in this context may be novel, studies on inflammation in OSA have shown varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children aged 6-11 years old Exclusion Criteria: * Previous upper airway surgery, genetic or syndromal disease, congenital or acquired neuromuscular disease, suspected or confirmed congenital or acquired immunodeficiency, obesity (BMI z-score ≥1.645), known metabolic syndrome, craniofacial abnormalities, structural or congenital heart disease, use of medications or therapy that could affect immunity such as systemic corticosteroids, chemotherapy, radiation therapy, intravenous immunoglobulins.
Where this trial is running
Hong Kong
- Prince of Wales Hospital — Hong Kong, Hong Kong (RECRUITING)
Study contacts
- Principal investigator: Kate Ching Ching Chan, MD — Chinese University of Hong Kong
- Study coordinator: Kate Ching Ching Chan, MD
- Email: katechan@cuhk.edu.hk
- Phone: 35053515
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obstructive Sleep Apnea