Investigating immune cell and microbiome interactions in ARDS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze the immune cell populations and their activation patterns, the cytokine-chemokine environment, and the lung microbiome in critically ill ICU patients with acute respiratory distress syndrome (ARDS). It will involve collecting bronchoalveolar lavage fluid and blood samples from patients categorized into none-to-mild and moderate-to-severe ARDS groups. The study seeks to understand how these factors relate to disease severity and progression, particularly focusing on T cell behavior and the microbiome's role in ARDS. Data will be collected within 72 hours of intubation and again after 7-10 days if the patient remains intubated.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Inclusion criteria - moderate-to-severe ARDS
* Admitted to the ICU at Hvidovre Hospital
* Intubated within the past 72 hours
* Moderate-to-severe ARDS according to the Berlin definition19
* Age ≥ 18 years

Inclusion criteria - none-to-mild ARDS

* Admitted to the ICU at Hvidovre Hospital
* Intubated within the past 72 hours
* None-to-mild ARDS according to the Berlin definition19
* Age ≥ 18 years

Exclusion Criteria:

* ARDS caused by COVID-19
* Absolute contraindications for bronchoscopy
* Untreated malignant arrhythmia
* Documented or suspected intracranial hypertension (intracranial pressure ≥ \> 15 mmHg)
* One-lung ventilation
* Severe coagulopathy

Where it's running

• Hvidovre Hospital, University of Copenhagen
  Hvidovre, Denmark Recruiting

Study contacts

• Study coordinator: MD, PhD, Ronni Plovsing
• Email: ronni.thermann.reitz.plovsing.01@regionh.dk
• Phone: +45386220721

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.