Investigating immediate versus delayed coronary angiography for cardiac arrest patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, randomized study aims to determine if performing acute coronary angiography within 120 minutes improves 30-day survival rates in patients who experience out-of-hospital cardiac arrest without ST-elevation on their ECG after restoration of spontaneous circulation. Participants will be randomly assigned to receive either immediate coronary angiography or delayed angiography, which may occur three days post-arrest. The study will include 1006 patients and will assess quality of life and health economics at six months, alongside extensive neurocognitive testing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Witnessed out of hospital cardiac arrest
* Restoration of Spontaneous Circulation (ROSC) \>20 minutes
* Coronary angiography is expected to be performed within 120 minutes from inclusion and randomization at hospital

Exclusion Criteria:

* Patient age \<18 years
* Obvious extracardiac genesis of cardiac arrest such as trauma, hemorrhagic shock, and / or asphyxia (eg drowning, suffocation, hanging, exposure to fire smoke)
* Terminally ill patients with a life expectancy of less than 1 year
* Patients with ST-elevation
* Known pregnancy
* Patient awake GCS \>8 (Glasgow Coma Scale)

Where it's running

• Aarhus University Hospital
  Aarhus, Denmark Recruiting
• Odense University hospital
  Odense, Denmark Recruiting
• Amsterdam UMC
  Amsterdam, Netherlands Recruiting
• Albert Schweitzer Hospital
  Dordrecht, Netherlands Recruiting
• Catharina Ziekenhuis
  Eindhoven, Netherlands Recruiting
• Treant Hospital
  Emmen, Netherlands Recruiting

Study contacts

• Principal investigator: Sten Rubertsson, Md,PhD — Uppsala Universtiy hospital
• Study coordinator: Sten Rubertsson Rubertsson, Md,PhD
• Email: sten.rubertsson@akademiska.se
• Phone: +46708693996

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.