Investigating how sugars affect fat accumulation in the liver

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines the impact of different sugars on hepatic fat content in male volunteers, both non-obese and obese. Participants will undergo a high-fat load intervention while receiving glucose, fructose, or sucrose, with measurements taken using magnetic resonance imaging and spectroscopy. The study aims to understand how these sugars influence fat storage in the liver, particularly in relation to non-alcoholic fatty liver disease (NAFLD). The findings could provide insights into dietary recommendations for managing liver health.

Why it matters

Who can join: the full rules

Part A

Inclusion Criteria:

* male volunteers - 15 nonobese subjects (Body Mass Index (BMI) \< 30 kg/m2) and 15 obese subjects (BMI ˃ 30 kg/m2)
* 18 - 70 years old

Exclusion Criteria:

* diabetes mellitus (fasting glucose above 7 mmol/l, 2-hour glucose after oGTT above 11.1 mmol/l, or antidiabetic treatment)
* other serious illnesses (cardiovascular disease, cancer, etc.)
* alcohol consumption ˃ 30 g/day
* fructose intolerance
* use of drugs affecting lipid metabolism

Part B

Inclusion Criteria:

* male volunteers with hepatic fat content higher than 6.2% and less than 16.5%, which corresponds to steatosis grade 2 (S2)
* 18 - 70 years old

Exclusion Criteria:

* diabetes mellitus (fasting glucose above 7 mmol/l, 2-hour glucose after oGTT above 11.1 mmol/l, or antidiabetic treatment)
* other serious illnesses (cardiovascular disease, cancer, etc.)
* alcohol consumption ˃ 30 g/day
* use of drugs affecting lipid metabolism
* intolerance of MR examination (claustrophobia, metal implants, etc.).

Where it's running

• Institute for Clinical and Experimental Medicine
  Prague, Czech Republic, Czechia Recruiting

Study contacts

• Principal investigator: Dita Pajuelo, PhD — Institute for Clinical and Experimental Medicine
• Study coordinator: Jan Kovář, PhD
• Email: nkov@ikem.cz
• Phone: 00420236053369

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.