Investigating how stress affects reality-monitoring in healthy individuals
Official title: Study of Reality-monitoring Process and Influence of Stress Using an Electrophysiological Approach
Run by Hôpital le Vinatier · NCT05595434 · Data updated 2026-11-12
This study is testing how stress affects the ability to remember where information comes from in healthy young adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 30 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Hôpital le Vinatier Academic / other |
| Locations | 1 site (Bron) |
| Status | Recruiting |
| Started | April 25, 2024 |
| Main results expected | October 25, 2025 |
| Study ends | November 16, 2025 |
| Registry record updated | July 24, 2025 |
| Trial ID | NCT05595434 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy, right-handed men and women aged 18 to 30 who are French speakers and readers.
✕Probably not a fit
Patients with a history of psychiatric disorders or those who do not meet the inclusion criteria will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the impact of stress on reality-monitoring, a cognitive process essential for remembering the source of information. Forty healthy participants aged 18 to 30 will undergo a standardized stress protocol, with half receiving an active stress condition and the other half a placebo. Participants will complete a reality-monitoring task while undergoing electrophysiological (EEG) recordings, along with socio-demographic and psychometric evaluations to assess the effects of stress on cognitive performance.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of the cognitive processes involved in stress and their implications for mental health, particularly in relation to psychotic disorders.
How similar studies have gone: While the effects of stress on cognitive processes have been studied, this specific investigation into reality-monitoring under stress conditions is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Right-handed Men and Women aged between 18 and 30 * Having given their written informed consent * For women: oral contraceptive use * French speakers and readers Exclusion Criteria: * Do not consent to be included in the study * Smokers * Night workers * Having visual or hearing impairments that could prevent the successful completion of tasks involving reading or listening to sounds * Taking drug treatment (except oral contraceptive) * Having a somatic pathology in particular neurological, endocrinal or blood circulation diseases (e.g., Raynaud's disease) * Having personal or first-degree relatives' history of diagnosed psychiatric disorders (according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders - DSM5) * Having psychotic prodomes measured by a score above 6 in the "prodomal questionnaire' - PQ-16 (Ising et al., 2012) * Having developed musical abilities (that is, regularly practicing a musical instrument) * Being pregnant or nursing
Where it's running
-
Centre Hospitalier le Vinatier
Bron, France Recruiting
Study contacts
- Principal investigator: Mondino Marine, PhD — hospital le vinatier
- Study coordinator: SARTLET Lydie
- Email: lydie.sartelet@ch-le-vinatier.fr
- Phone: 0437915531
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How age affects germinal center responses after flu and rabies vaccines
Researchers will test how the immune system responds to flu and rabies vaccines in younger adults (18–40) and older adults (65+).
-
Magnetic field maps with NV sensors for non-invasive heart measurements
This study tests whether diamond-based NV magnetometers can non-invasively detect and map the heart's magnetic field in healthy adults.
-
Methylation analyses using home-based self-sampling in women with and without gynecological disease
This study tests whether self-collected urine and vaginal samples can reveal DNA methylation markers that distinguish people with gynecological (pre-)cancers from cancer-free controls.
-
Omega-3 status in healthy adults: comparing different fish-oil and algae-oil products
This study tests whether various fish-oil and algae-oil products can raise the Omega-3 Index in healthy adults who don’t eat much fatty fish.
-
A safe, carefully dosed test of TBD11 in healthy adults
This phase 1 study tests TBD11 in healthy adults to see if it is safe and tolerable and to understand how it behaves in the body, including how it interacts with other medicines.
-
Fosmanogepix in healthy adults: how it may interact with other drugs and heart rhythm
This study tests whether fosmanogepix (and its active form manogepix) changes how other medicines work in healthy adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.