Investigating how sleep reactivity affects shift work disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to test the role of sleep reactivity as an independent cause of Shift Work Disorder (SWD). It will involve a two-step mechanistic randomized controlled trial design with 150 participants who have SWD and varying levels of sleep reactivity. The first step will experimentally reduce circadian misalignment, while the second step will assess the impact of Cognitive Behavioral Therapy (CBT) on those who remain symptomatic. The study seeks to establish sleep reactivity as a predictor of insomnia and sleepiness in SWD, independent of circadian factors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants must be working a fixed nightshift schedule, operationalized as: a) working at least three night shifts a week, b) shifts must begin between 18:00 and 02:00, and last between 8 to 12 hours, and c) must also plan to maintain the nightshift schedule for the duration of the study
* Participants must have Shift Work Disorder, which will be diagnosed based on ICSD-3 criteria
* Participants must show circadian misalignment, operationalized as a baseline melatonin onset between 18:00 and 01:00.
* Participants must be at least 18 years old

Exclusion Criteria:

* Insomnia disorder or excessive sleepiness predating the onset of shift work
* Termination of nightshift schedule
* Presence of other sleep disorders (e.g. obstructive sleep apnea, narcolepsy) determined by standard clinical polysomnography
* Diagnosis of bipolar disorder
* History of neurological disorders determined by self-report and medical history
* Pregnancy
* Alcohol use disorder
* Illicit drug use via self-report and urine drug screen if reasonable suspicion to test

Where it's running

• Henry Ford Columbus Medical Center
  Novi, Michigan, United States Recruiting

Study contacts

• Study coordinator: Philip Cheng, PhD
• Email: pcheng1@hfhs.org
• Phone: 248-344-7361

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Impact of Night Shifts on Glucose and Lipid Metabolism in Hospital Workers

  This study tests whether night shift work is linked to changes in blood sugar, fats, and overall metabolic health in hospital staff.

  Recruiting at 2 sites German Institute of Human Nutrition · Berlin and 1 other locations · NCT07426211

• Evaluating Solriamfetol for Excessive Sleepiness in Shift Workers

  This study is testing if a new medication called solriamfetol can help adults with excessive sleepiness from shift work feel more awake and alert.

  Recruiting at 46 sites Phase 3 Axsome Therapeutics, Inc. · Auburn, Alabama and 48 other locations · NCT06568367

• Exploring the effects of sleep loss on aging and cognitive decline

  This study is testing how not getting enough sleep affects thinking and aging in healthy people and those with memory problems or Alzheimer's disease.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT06492109

• Impact of Night Shift Work on Obesity Risk in Workers

  This study is trying to see if working night shifts makes hospital and industry workers more likely to become obese compared to those who work during the day.

  Recruiting University of Vienna · Vienna, State of Vienna · NCT06288568

• Exploring dietary impacts on night shift EMS providers' health

  This study is testing how different diets can affect blood sugar levels in EMS workers who work night shifts to see if changing what they eat can help their health.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT05153759

• Effects of whey protein on health in night shift workers

  This study tests if taking a whey protein supplement can help night shift workers improve their metabolic health compared to a placebo drink.

  Recruiting University of Adelaide · Adelaide, South Australia · NCT04869098

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.