Investigating how sleep affects memory in children with focal epilepsy
Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.
NA · University Hospital, Strasbourg, France · NCT03865771
This study is testing how sleep affects memory in children with certain types of epilepsy to see if sleep problems make it harder for them to learn.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 95 (estimated) |
| Ages | 6 Years to 13 Years |
| Sex | All |
| Sponsor | University Hospital, Strasbourg, France (other) |
| Locations | 2 sites (Nancy and 1 other locations) |
| Trial ID | NCT03865771 on ClinicalTrials.gov |
What this trial studies
This study examines the relationship between sleep and memory consolidation in children diagnosed with age-related focal epilepsies, specifically benign epilepsy with centro temporal spikes, atypical benign partial epilepsy, and epileptic encephalopathy with continuous spike and waves during sleep. The researchers hypothesize that epileptic activity during sleep disrupts memory consolidation, leading to learning difficulties. Participants will undergo neuropsychological testing, video EEG, and polysomnography to assess their sleep patterns and memory function. The study aims to better understand how these conditions affect cognitive development in children.
Who should consider this trial
Good fit: Ideal candidates include children with focal age-related epilepsy who have normal psychomotor development and are hospitalized for follow-up.
Not a fit: Patients with psychiatric disorders, significant sensory impairments, or abnormal neuroimaging results may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing memory and learning in children with focal epilepsy.
How similar studies have performed: While the specific approach of this study may be novel, there is existing literature suggesting that sleep plays a critical role in memory consolidation, particularly in children with neurological conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Principal: * normal psychomotor development * informed consent signed by both parents and subject if able * affiliated to social security regimen Specific Patients from "severe" and "benign" groups: * focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria) * children hospitalized for their follow-up * normal neuroimaging Control group -children hospitalized for a non neurologic disease Exclusion Criteria: Principal: Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French language Minor under care Specific Patients from "severe" and "benign" groups: * degenerative disease * abnormal neuroimaging * mental deficiency Control group * neurologic trouble * abnormal sleep EEG * intellectual deficiency
Where this trial is running
Nancy and 1 other locations
- Hopital D'Enfants Pediatrie Medicale Ambulatoire — Nancy, France (RECRUITING)
- Hopital de Hautepierre-Service de Pediatrie/Neurologie — Strasbourg, France (RECRUITING)
Study contacts
- Principal investigator: Anne DE SAINT MARTIN, MD — Hôpitaux Universitaires de Strasbourg
- Study coordinator: Anne DE SAINT MARTIN, MD
- Email: anne.desaintmartin@chru-strasbourg.fr
- Phone: + 33 3.88.12.83.98
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Benign Epilepsy With Centro Temporal Spikes, Atypical Benign Partial Epilepsy, Epileptic Encephalopathy With Continuous Spike and Waves During Sleep, Memory consolidation, Epilepsy, Childhood, Benign epilepsy with centro temporal spikes, Epileptic encephalopathy with continuous spike and waves during sleep