Investigating how sex hormones affect gut microbiome and heart health in transgender individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the impact of sex hormones on the gut microbiome and the potential development of cardiovascular risk factors in transgender individuals undergoing hormone replacement therapy. Over two years, 200 healthy participants will be monitored for changes in their microbiome, metabolome, and immune system, while also assessing cardiovascular disease phenotypes. Utilizing advanced scientific methods, the study aims to quantify the influence of sex hormones on cardiovascular risk markers for the first time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-50
* Language requirements: German, English
* Previous gender hormone replacement therapy (HRT).
* Ability to give consent and written consent to participate.
* Health insurance (for clarification of incidental findings)

Exclusion Criteria:

* Diseases or functional disorders that, in the opinion of the study physician, preclude participation in the study.
* Incapacity or other circumstances that do not allow study participants to fully understand the nature, significance and scope of this study.

Where it's running

• Experimental and Clinical Research Center, Clinical Research Unit
  Berlin, Germany Recruiting

Study contacts

• Principal investigator: Lajos Marko — Charite - Universitätsmedizin Berlin
• Study coordinator: Sofia Forslund, Prof. Dr.
• Email: sofia.forslund@mdc-berlin.de
• Phone: +49 30 450540649

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Overnight Temperature Regulation to Test Gut Health, Inflammation, and Circadian Rhythms

  This study tests whether two weeks of using the Eight Sleep Pod at night can improve gut bacteria balance, lower inflammation, and strengthen daily temperature and blood pressure rhythms in postmenopausal women and age-matched men with poor sleep.

  Recruiting Eight Sleep Inc. · Newton Center, Massachusetts · NCT07848594

• Egg intake and gut health, HDL, and immune markers in adults

  This study tests whether daily egg whites or whole eggs affect gut microbiome, HDL function, metabolism, and immune profiles in adults with a range of BMIs.

  Recruiting University of Connecticut · Storrs, Connecticut · NCT07844616

• Tiny Tummies: Milk vs. Oat Milk for Toddlers

  This 12‑month randomized study will test whether 12‑month‑old toddlers who drink daily cow’s milk dairy vs. oat milk dairy have better growth, sleep, neurocognitive outcomes, and gut microbiome by 24 months.

  Recruiting Arizona State University · Phoenix, Arizona · NCT07839156

• Probiotic supplementation to support gut health, immune response, and well-being in adults

  In this 8-week study, healthy adults with mild to moderate stress will take a probiotic supplement or placebo daily to see if it affects gut barrier function, immune markers, and well-being.

  Recruiting Orthomol Pharmazeutische Vertiebs GmbH · Trier · NCT07779265

• Peanuts and stress: does eating peanuts affect heart health markers in people under high stress

  This study tests whether adding roasted peanuts to the diet can improve immune and cardiovascular risk markers in adults who report high chronic stress.

  Recruiting USDA, Western Human Nutrition Research Center · Davis, California · NCT07735221

• Immunomodulatory effects of Spirulina Blue Protein capsules in healthy adults

  This study tests whether Spirulina Blue Protein capsules can modulate immune function in healthy adults over 12 weeks, compared with a placebo.

  Recruiting University of Phayao · Phayao, Changwat Phayao · NCT07733362

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.