Investigating how salt affects blood pressure in young adults born prematurely
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
EARLY_PHASE1 · Wake Forest University Health Sciences · NCT04026776
This study is testing how salt affects blood pressure in young adults who were born prematurely to see if dietary changes and a medication can help improve their heart health.
Quick facts
| Phase | EARLY_PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 22 Years to 33 Years |
| Sex | All |
| Sponsor | Wake Forest University Health Sciences (other) |
| Locations | 1 site (Winston-Salem, North Carolina) |
| Trial ID | NCT04026776 on ClinicalTrials.gov |
What this trial studies
This research aims to understand the impact of dietary salt on blood pressure in young adults who were born preterm. The study will explore the mechanisms behind hypertension and cardiovascular disease in this population, comparing them to healthy peers born at term. Participants will receive interventions including allopurinol and dietary modifications to assess their effects on salt sensitivity and cardiovascular function. The findings could lead to better prevention and treatment strategies for cardiovascular issues in individuals born prematurely.
Who should consider this trial
Good fit: Ideal candidates include young adults who were born preterm at less than 34 weeks gestational age.
Not a fit: Patients who were born at term or those with significant health issues such as chronic kidney disease or heart failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights that lead to improved prevention and treatment strategies for hypertension and cardiovascular disease in young adults born preterm.
How similar studies have performed: Other studies have indicated the importance of understanding salt sensitivity and its relationship to blood pressure, suggesting that this approach could yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Singleton birth * Born at less than 34 weeks gestational age (preterm cohort) * Born at greater than 36 weeks gestational age (term cohort) Exclusion Criteria: * Twin birth * Congenital anomalies or genetic syndromes * Currently pregnant or breast feeding * Subject-reported history of hypertension * Current use of antihypertensive medications * Active cancer * Chronic kidney disease * Heart failure * Liver failure
Where this trial is running
Winston-Salem, North Carolina
- Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States (RECRUITING)
Study contacts
- Principal investigator: Hossam Shaltout, PhD — Wake Forest University Health Sciences
- Study coordinator: Hossam Shaltout, PhD
- Email: hshaltou@wakehealth.edu
- Phone: 336-716-1251
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Salt, Excess, Blood Pressure Disorders, Uric Acid sensitivity, Salt sensitivity, Blood Pressure Influences