Investigating how oxytocin affects blood sugar levels
The Role of Oxytocin in Regulating Blood Glucose
NA · University Hospital, Gentofte, Copenhagen · NCT06334172
This study is testing whether oxytocin can affect blood sugar levels and hormone release in healthy men with a normal weight.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 20 Years to 50 Years |
| Sex | Male |
| Sponsor | University Hospital, Gentofte, Copenhagen (other) |
| Locations | 1 site (Hellerup, Capital Region) |
| Trial ID | NCT06334172 on ClinicalTrials.gov |
What this trial studies
This study examines the impact of oxytocin on insulin and glucagon secretion in healthy men with a body mass index under 27 kg/m2. Participants will undergo a graded glucose infusion test while receiving either synthetic oxytocin or a placebo in a randomized, double-blinded manner. The research aims to determine how oxytocin influences glucose-stimulated hormone secretion and will also measure changes in various metabolic markers.
Who should consider this trial
Good fit: Ideal candidates are healthy men with a body mass index between 19 and 25 kg/m2.
Not a fit: Patients with diabetes or significant health issues such as heart, liver, or kidney disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new treatments for glucose metabolism disorders, potentially improving blood sugar regulation.
How similar studies have performed: While the role of oxytocin in glucose metabolism is being explored, this specific approach is relatively novel and has not been extensively tested in similar studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI 19-25 kg/m2 Exclusion Criteria: * Diabetes * Heart-, liver or kidney disease * More than 14 units of alcohol weekly, or drug abuse * Smoking or any kind of nicotine products * Alanin aminotransferase (ALAT) ≥ 2 × normal range * Estimated glomerular filtration rate (eGFR) \< 60 ml/min/1,73m2 or creatinine above normal range * Blood pressure \> 140/90 * Hemoglobin \< normal range * Corrected QT Interval (Qtc) \>0,45 sec. at electrocardiogram (ECG) at screening * Known disease in the pituitary gland or previous pituitary surgery * Any other disease/condition which the trial managers believe may affect participation in the trial
Where this trial is running
Hellerup, Capital Region
- Center for Clinical Metabolic Research, Gentofte Hospital — Hellerup, Capital Region, Denmark (RECRUITING)
Study contacts
- Study coordinator: Vivian Kliim-Hansen, MD
- Email: vivian.kliim-hansen@regionh.dk
- Phone: +4524476875
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Glucose Metabolism Disorders, oxytocin, blood glucose, glucose stabilization