Investigating how oxytocin affects blood sugar levels

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the impact of oxytocin on insulin and glucagon secretion in healthy men with a body mass index under 27 kg/m2. Participants will undergo a graded glucose infusion test while receiving either synthetic oxytocin or a placebo in a randomized, double-blinded manner. The research aims to determine how oxytocin influences glucose-stimulated hormone secretion and will also measure changes in various metabolic markers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* BMI 19-25 kg/m2

Exclusion Criteria:

* Diabetes
* Heart-, liver or kidney disease
* More than 14 units of alcohol weekly, or drug abuse
* Smoking or any kind of nicotine products
* Alanin aminotransferase (ALAT) ≥ 2 × normal range
* Estimated glomerular filtration rate (eGFR) \< 60 ml/min/1,73m2 or creatinine above normal range
* Blood pressure \> 140/90
* Hemoglobin \< normal range
* Corrected QT Interval (Qtc) \>0,45 sec. at electrocardiogram (ECG) at screening
* Known disease in the pituitary gland or previous pituitary surgery
* Any other disease/condition which the trial managers believe may affect participation in the trial

Where it's running

• Center for Clinical Metabolic Research, Gentofte Hospital
  Hellerup, Capital Region, Denmark Recruiting

Study contacts

• Study coordinator: Vivian Kliim-Hansen, MD
• Email: vivian.kliim-hansen@regionh.dk
• Phone: +4524476875

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.