Investigating how oral iron doses affect serum ferritin levels in iron-deficient women
Assessing the Immediate Increase in Serum Ferritin After Oral Iron Doses: an Experimental Study in Iron-deficient Women
This study tests how different doses of iron supplements affect iron levels in women aged 18 to 45 who have low iron but are not anemic.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Swiss Federal Institute of Technology Academic / other |
| Locations | 1 site (Zurich, Canton of Zurich) |
| Trial ID | NCT06851130 on ClinicalTrials.gov |
What this trial studies
This study examines the immediate effects of oral iron supplementation on serum ferritin levels in women with low iron stores but no anemia. Participants will receive either 80 mg or 160 mg of ferrous sulfate daily for two months to assess how these doses influence serum ferritin levels over time. The goal is to understand the acute changes in ferritin levels to improve monitoring of iron status during supplementation. The study focuses on women aged 18 to 45 with specific eligibility criteria to ensure accurate results.
Who should consider this trial
Good fit: Ideal candidates are women aged 18 to 45 with low serum ferritin levels and no anemia.
Not a fit: Patients with chronic diseases, recent blood loss, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved guidelines for monitoring iron supplementation in women with iron deficiency.
How similar studies have performed: While studies on iron supplementation exist, this specific investigation into acute serum ferritin response is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Low iron stores (SF levels \< 30 µg/L), * no anemia (Hb \> 120 g/L) * no inflammation (CRP \< 5 mg/L) * 18 to 45 years old. * Body weight \<70 kg * Normal body Mass Index (18.5-26.5 kg/m2) Exclusion Criteria: * Any chronic or acute disease * Consumption of mineral and vitamin supplements since screening and over the study period * Blood transfusion, blood donation or significant blood loss over the past 4 months, * Pregnant or breastfeeding, * Continuous/long-term use of medication during the whole studies (except for contraceptives) * Therapeutic iron infusion over the past 6 months, * Known hypersensitivity or allergy to iron supplements, * Intention to become pregnant over the course of the study
Where this trial is running
Zurich, Canton of Zurich
- Laboratory of Nutrition and Metabolic Epigenetics — Zurich, Canton of Zurich, Switzerland (Recruiting)
Study contacts
- Study coordinator: Nicole Stoffel, PhD
- Email: nicole.stoffel@hest.ethz.ch
- Phone: +41 44 632 83 93
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.