Investigating how obesity affects fat tissue structure
Effect of Obesity on Extracellular Matrix Composition in Healthy Males With Normal and High BMI
This study is trying to see how obesity and age change the structure of fat tissue in young and older men.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | Male |
| Sponsor | University of Copenhagen Academic / other |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT06304506 on ClinicalTrials.gov |
What this trial studies
This study examines the composition of the extracellular matrix in adipose tissue among three groups: young healthy men, older healthy men, and obese young men. Each group consists of 10 participants, and the study aims to identify differences in the adipose tissue matrix between these populations. Participants undergo a series of assessments including body composition analysis, blood pressure measurement, blood sampling, and adipose tissue biopsy, followed by exercise testing to evaluate fat oxidation and oxygen uptake. The findings may provide insights into how obesity and age influence fat tissue characteristics.
Who should consider this trial
Good fit: Ideal candidates include healthy men aged 18-35 with a BMI of 20-25, obese men aged 18-35 with a BMI of 30-40, and healthy older men aged 60-75 with a BMI of 20-25.
Not a fit: Patients with cardiovascular disease, chronic inflammatory diseases, or those taking medications that affect substrate use will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of obesity's impact on fat tissue, potentially leading to improved treatments for obesity-related conditions.
How similar studies have performed: While similar studies have explored aspects of adipose tissue composition, this specific investigation into the extracellular matrix in relation to obesity and age is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy men aged \[18,35\] and BMI \[20,25\] * Obese men aged \[18,35\] and BMI \[30,40\] * Healthy older men aged \[60,75\] and BMI \[20,25\] Exclusion Criteria: * Present or former cardiovascular disease and chronical inflammatory disease * Consumption of medications and supplements that influence substrate use at rest and/or during exercise
Where this trial is running
Copenhagen
- Xlab, Faculty of Health and Medical Sciences, University of Copenhagen — Copenhagen, Denmark (Recruiting)
Study contacts
- Principal investigator: Jørn W Helge, PhD — University of Copenhagen
- Study coordinator: Jørn Wulff W Helge, PhD
- Email: jhelge@sund.ku.dk
- Phone: +4528757506
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.