Investigating how nitrate affects red blood cells in people with type 2 diabetes
The Effect of Dietary Nitrate Supplementation on Red Blood Cell Function in Patients with Type 2 Diabetes
This study is testing if drinking beetroot juice can improve how well red blood cells work in people with type 2 diabetes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Trial ID | NCT04917471 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the impact of nitrate supplementation, specifically through beetroot juice, on the function of red blood cells in individuals diagnosed with type 2 diabetes. Participants will be randomly assigned to receive either the beetroot juice or a placebo juice to assess any differences in red blood cell performance. The study will focus on understanding how nitrate may influence blood flow and oxygen delivery in this patient population. By examining these effects, the research seeks to provide insights into potential dietary interventions for managing diabetes.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with type 2 diabetes who do not have any of the exclusion criteria.
Not a fit: Patients with acute coronary syndrome, heart failure, or those on a vegetarian diet may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new dietary recommendations that improve red blood cell function and overall health in patients with type 2 diabetes.
How similar studies have performed: While there is limited research specifically on nitrate's effects on red blood cells in diabetes, similar studies on dietary nitrates have shown promising results in other cardiovascular contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Type 2 diabetes Exclusion Criteria: Acute coronary syndrome Vegetarian diet Impaired renal function Absolute indication for proton pump inhibitor Ongoing treatment with organic nitrate Heart failure (ejection fraction \<35%) Any condition that interferes with the possibility to fulfill the study protocol
Where this trial is running
Stockholm
- Karolinska Institutet, Karolinska University Hospital — Stockholm, Sweden (Recruiting)
Study contacts
- Principal investigator: John Pernow — Karolinska Institutet
- Study coordinator: John Pernow
- Email: john.pernow@ki.se
- Phone: +46704848361
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.