Investigating how men and women regulate blood flow in the brain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study explores the differences in cerebral blood flow (CBF) regulation between men and women, particularly under stress conditions like low oxygen or high carbon dioxide. By administering various medications and using advanced MRI techniques, the researchers aim to uncover the physiological mechanisms that contribute to these differences. The study focuses on healthy adults aged 18-40, minimizing confounding factors such as age and comorbidities. The ultimate goal is to enhance understanding of cerebrovascular disease risk and its relationship with sex and hormonal influences.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All participants will be healthy adults between 18-40 years old, matched for age and aerobic fitness
* Participants will be non-hypertensive (\<125/80mm Hg)
* Participants will be non-obese (BMI 19-25 kg/m2)
* Participants will have normal blood glucose (\<100 g/dl)
* Participants will have normal lipids (LDL cholesterol \<130 mg/dl, triglycerides \<150 mg/dl)
* Women must have a natural regular menstrual cycle

Exclusion Criteria:

* Participants with a history of:

  * peripheral vascular disease
  * hepatic disease
  * renal disease
  * hematologic disease
  * stroke
  * obesity
  * prediabetes
  * diabetes
  * sleep apnea
* Participants with current BP\>130/85 mmHg
* Regular smokers
* Taking cardiovascular medications
* Women who take hormonal birth control
* Women who are pregnant or have polycystic ovarian syndrome \[Hormonal birth control will not be allowed in women\]
* Contradictions to MRI
* Lactose intolerance

Where it's running

• University of Wisconsin, Madison
  Madison, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: William Schrage, PhD — University of Wisconsin, Madison
• Study coordinator: Shawn E Bolin, MS
• Email: sbolin@wisc.edu
• Phone: 608-263-6308

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pulse treatment for acute ischemic stroke

  This study is testing a new treatment called the Pulse NanoMED System for people who have had an acute ischemic stroke to see if it can help improve blood flow to the brain after they receive standard care.

  Recruiting Euphrates Vascular, Inc. · Columbia, South Carolina · NCT06052969

• Coronary CT angiography–guided calcium modification during PCI for calcified coronary artery disease

  This study will see if using CT angiography to plan calcium treatment before stenting helps people with flow-limiting, calcified coronary artery disease have better stent results and faster procedures compared with the usual ultrasound-guided PCI while keeping similar safety.

  Recruiting at 10 sites Fundación EPIC · Boston, Massachusetts and 14 other locations · NCT07286578

• Freesolve resorbable magnesium scaffold vs. Xience stent for up to two new heart artery lesions

  This trial tests whether the Freesolve resorbable magnesium scaffold works as well as the Xience drug-eluting stent for treating up to two new coronary artery lesions in adults.

  Recruiting at 3 sites Teleflex · Washington D.C., District of Columbia and 2 other locations · NCT07258290

• Single versus dual antiplatelet therapy after drug-coated balloon angioplasty in elderly or high-bleeding-risk patients

  This study tests whether taking one antiplatelet medicine is as safe and causes less bleeding than taking two medicines for people aged 75 or older, or adults at high bleeding risk, after drug-coated balloon angioplasty for coronary artery disease.

  Recruiting Fondazione Ricerca e Innovazione Cardiovascolare ETS · Milan, MI · NCT06535568

• Using two stent retrievers at once versus one for treating acute ischemic stroke

  We will test whether using two stent retrievers at the same time helps people with acute ischemic stroke get their blocked artery opened faster and recover better during mechanical thrombectomy.

  Recruiting at 4 sites Fundación EPIC · Essen and 3 other locations · NCT05930145

• Long-term follow-up of Intergard vascular grafts and patches

  This registry will see how Intergard grafts and patches perform and stay safe over time in adults who had bypass, repair, or replacement of the aorta, carotid, or peripheral arteries.

  Recruiting at 5 sites Intervascular · Hershey, Pennsylvania and 4 other locations · NCT07322913

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.