Investigating how maternal characteristics affect child growth and obesity
Maternal Characteristics Associated With Child Growth and Adiposity. Search for Nutrigenomic Biomarkers in Peripheral Blood
This study looks at how hormone levels in breastfeeding mothers affect their children's growth and risk of obesity.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 130 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri Academic / other |
| Locations | 1 site (La Plata, Buenos Aires) |
| Trial ID | NCT05798676 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between maternal hormone levels and child growth and adiposity. It will analyze concentrations of leptin, insulin, LEAP2, and cortisol in both plasma and breast milk from lactating women with normal weight and those with pre-pregnancy overweight or obesity. Participants will provide milk and blood samples, allowing researchers to compare the hormonal profiles and their associations with infant growth and obesity outcomes. The study seeks to understand how maternal and infant hormones and their receptors influence child development.
Who should consider this trial
Good fit: Ideal candidates for this study are lactating women with pre-pregnancy normal weight or overweight/obesity.
Not a fit: Patients with diabetes, multiple pregnancies, hypertensive disorders during pregnancy, or those who delivered pre-term infants will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how maternal health impacts child growth and obesity, potentially guiding interventions for at-risk populations.
How similar studies have performed: While similar studies have explored maternal influences on child health, this specific focus on hormonal associations in the context of obesity is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Lactating women with pre-pregnancy normal weight and overweight or obesity as described by the World Health Organization. Exclusion Criteria: * Diabetes (Type I or II or gestational) * Multiple pregnancy * Hypertensive disorders during pregnancy * Delivery of pre-term infant (\<37 weeks).
Where this trial is running
La Plata, Buenos Aires
- Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri — La Plata, Buenos Aires, Argentina (Recruiting)
Study contacts
- Principal investigator: Maria F Andreoli, BsC — Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri
- Study coordinator: Maria F Andreoli, PhD
- Email: mfandreoli@gmail.com
- Phone: 54 221 4535901
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.