Investigating how male-specific antibodies affect the sex ratio of sperm
Effects of Male-specific Antibodies on Sex Ratio
This study looks at how antibodies from men who have had a vasectomy might affect the chances of having male or female babies when using their sperm for assisted reproduction.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 25 Years and up |
| Sex | Male |
| Sponsor | Odense University Hospital Academic / other |
| Locations | 1 site (Odense) |
| Trial ID | NCT02267252 on ClinicalTrials.gov |
What this trial studies
This observational study examines the role of antibodies from vasectomized men in binding to Y-spermatozoa, which may help explain the lower sex ratio observed after microinsemination using epididymal sperm from these men. The study focuses on understanding the interaction between sperm antibodies and sperm cells to provide insights into reproductive outcomes. By analyzing the binding capabilities of these antibodies, researchers aim to uncover potential factors influencing sex ratio variations in assisted reproductive technologies.
Who should consider this trial
Good fit: Ideal candidates for this study are vasectomized men who can comprehend the study information.
Not a fit: Men who do not understand the study information will not benefit from participation.
Why it matters
Potential benefit: If successful, this study could enhance understanding of factors affecting sex ratios in assisted reproduction, potentially leading to improved reproductive strategies.
How similar studies have performed: While this study explores a specific interaction, similar studies have not extensively investigated the role of male-specific antibodies in sex ratio outcomes, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Vasectomized men Exclusion Criteria: * Men who do not understand the study information
Where this trial is running
Odense
- Fertility Clinic, Odense University Hospital — Odense, Denmark (Recruiting)
Study contacts
- Study coordinator: Jens Fedder, MD, PhD
- Email: fedder@dadlnet.dk
- Phone: +45 26820368
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.