Investigating how macrophages respond to lung inflammation after endotoxin exposure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the role of alveolar macrophages in lung inflammation and repair following exposure to endotoxins. The researchers hypothesize that resident and recruited macrophages have distinct yet complementary functions in managing inflammation and facilitating tissue repair. Participants will undergo bronchoscopy with the administration of lipopolysaccharide to assess macrophage behavior and response. The goal is to better understand the mechanisms of alveolar repair in conditions like Acute Respiratory Distress Syndrome (ARDS).

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Written, informed consent
2. Age 18-50

Exclusion Criteria:

1. Current or recent illness (past 2 weeks)
2. Presence or prior history of cardiac, pulmonary or systemic disease
3. Bleeding disorder, use of systemic anticoagulants or antiplatelet therapy
4. American Society of Anesthesiology (ASA) class 2 or greater
5. Immunocompromised state (HIV, immunoglobulin deficiency, systemic immunosuppressants)
6. Use of any inhaled substance, including tobacco, marijuana, e-cigarrettes, cocaine, methamphetamines, or toxic vapors in the past 3 months or greater than 10 pack-year smoking history
7. Alcohol use disorder or greater than 7 drinks/week for women or greater than 14 drinks/week for men in the past 3 months
8. Allergy or prior adverse reaction to lidocaine, midazolam or fentanyl
9. Abnormal spirometry or electrocardiogram at time of screening
10. Pregnant (based on urine pregnancy test) or breast feeding

Where it's running

• National Jewish Health
  Denver, Colorado, United States Recruiting

Study contacts

• Study coordinator: Kara Mould
• Email: mouldk@njhealth.org
• Phone: 303-398-1787

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.