Investigating how lung volume affects throat collapse during sleep endoscopy for sleep apnea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the relationship between lung volume and upper airway patency during drug-induced sleep endoscopy (DISE) in patients with obstructive sleep apnea (OSA). Participants will undergo DISE as part of their routine surgical evaluation for OSA, where a negative pressure ventilator will be used to manipulate lung volume. The goal is to better understand how lung function influences throat collapse, which could improve surgical outcomes for OSA patients. By exploring these pathophysiological factors, the study aims to enhance the selection process for surgical candidates and potentially lead to new treatment options.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥ 18 yrs) willing and capable of providing informed consent
* Obstructive sleep apnea (AHI ≥ 5 events/hour)
* Must be willing and able to provide informed consent to participate in the study.
* Interested in surgical treatments of OSA and have consented for a DISE procedure as part of their routine clinical evaluation.

  * Patients are evaluated and cleared by anesthesia prior to the procedure.

Exclusion Criteria:

* No significant uncontrolled medical co-morbidities (e.g., uncontrolled hypertension, unstable angina, uncompensated heart failure or COPD).
* Any medical comorbidity that would prevent the patient from receiving anesthesia or having surgery
* Inability to tolerate negative pressure ventilator or perform PFT (i.e. claustrophobia)
* No incapacitating disability that interferes with execution of the protocol

Where it's running

• Emory University Hospital Midtown
  Atlanta, Georgia, United States Recruiting

Study contacts

• Principal investigator: Jason Yu, MD — Emory University
• Study coordinator: Jason Yu, MD
• Email: jyu40@emory.edu
• Phone: 470-763-3887

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.