Investigating how lung function affects exercise performance in trained individuals
Official title: Role of Lung Function, Airway Inflammation and Bronchial Hyper Reactivity for Exercise Capacity in Well-trained Individuals
Run by University of Copenhagen · NCT06077019 · Data updated 2026-11-12
This study is testing if using certain inhalers can improve how well young, physically active people can perform during exercise by looking at their lung function.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 39 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University of Copenhagen Academic / other |
| Locations | 1 site (Copenhagen) |
| Status | Recruiting |
| Started | October 3, 2023 |
| Main results expected | July 15, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | April 9, 2025 |
| Trial ID | NCT06077019 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are physically active individuals aged 18-39 who engage in more than 5 hours of exercise weekly and have high maximal oxygen consumption.
✕Probably not a fit
Patients with severe asthma or other significant respiratory issues, as well as those with certain chronic illnesses or who smoke, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to explore the relationship between lung function and exercise capacity in physically active individuals aged 18-39. Participants will undergo prolonged inhalation of beta2-agonists, specifically vilanterol combined with fluticasone furoate or indacaterol combined with mometasone furoate, alongside a placebo group. The study will assess how these interventions impact exercise performance, particularly focusing on maximal oxygen consumption. The findings could provide insights into optimizing exercise capacity through respiratory interventions.
Why it matters
Potential benefit: If successful, this study could enhance exercise performance strategies for well-trained individuals by optimizing lung function.
How similar studies have gone: While the specific combination of interventions may be novel, similar studies investigating lung function and exercise performance have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-39 * Physically active \> 5 h weekly * Maximal oxygen consumption classified as high or very high Exclusion Criteria: * Diagnosed with severe asthma and been in treatment with long-acting beta2-agonist/corticosteroid * ECG abnormality * ACQ score \> 1.5 * Severe bronchial hyperreactivity as determined by mannitol test * FEV1/FVC ratio \< 0.7 determined with spirometry * Chronic illness determined to be a potential risk for participant during study * In chronic treatment with medication that may interfere with study results * Pregnancy * Smoker * Blood donation during the past 3 months
Where it's running
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August Krogh Building
Copenhagen, Denmark Recruiting
Study contacts
- Principal investigator: Morten Hostrup, PhD — University of Copenhagen
- Study coordinator: Morten Hostrup, PhD
- Email: mhostrup@nexs.ku.dk
- Phone: +4535321595
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.