Clinical trial Recruiting at 1 site Interventional Ages 18 to 59 Women only

Investigating how limited ankle movement affects squats in people with knee pain

Official title: Limited Ankle Dorsiflexion and Effect on Single Limb Squats in Individuals With Patellofemoral Pain: Interventions and Outcomes in a Randomized Clinical Trial

Run by Loma Linda University · NCT05285007 · Data updated 2026-11-12

This study is testing if improving ankle movement can help people with knee pain do single limb squats better.

More Patellofemoral Pain Syndrome trials

Quick facts

Study typeInterventional
Ages18 Years to 59 Years
SexWomen only
Enrollment60 (estimated)
SponsorLoma Linda University
Academic / other
Locations1 site (Loma Linda, California)
StatusRecruiting
StartedMarch 2, 2022
Main results expectedMay 2027
Study endsMay 2027
Registry record updatedAugust 20, 2026
Trial IDNCT05285007 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are females aged 18-59 with a history of active patellofemoral pain for at least 6 months and limited ankle dorsiflexion.

Probably not a fit

Patients with a history of musculoskeletal surgery, current knee effusion, or significant resting pain may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research examines the connection between limited ankle dorsiflexion and its impact on single limb squats in individuals suffering from patellofemoral pain. Participants will be randomly assigned to either an experimental group, which will receive interventions aimed at increasing dorsiflexion, or a minimal intervention group that will engage in light activities. The study will involve measuring dorsiflexion range of motion, hip abductor strength, and performance on the Lateral Step Down test using motion capture technology. The goal is to understand how improving ankle mobility may influence knee pain and function during specific movements.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies for individuals with patellofemoral pain by enhancing their functional movement capabilities.

How similar studies have gone: While the specific approach may be novel, similar studies have indicated that addressing ankle mobility can positively affect knee function and pain.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* History of active Patellofemoral Pain for at least 6 months
* No clinic based therapeutic interventions for a 6-month period prior to testing
* Females aged 18-59 years' old
* Limited ankle dorsiflexion as noted by \<45degs using the weight bearing lunge test

Exclusion Criteria:

* History of musculoskeletal surgery or fractures on the tested leg or lumbar spine that could affect their biomechanics during the study
* History of soft tissue or skeletal abnormalities in the tested limb
* Current knee effusion
* Resting pain greater than 5/10

Where it's running

  • Loma Linda University
    Loma Linda, California, United States
    Recruiting

Study contacts

  • Principal investigator: Everett Lohman, Dsc — Loma Linda University
  • Study coordinator: Everett Lohman, DSc
  • Email: elohman@llu.edu
  • Phone: 909-558-4632

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.