Investigating how lead exposure affects brain cell death pathways
Effects of Lead Exposure on Iron Metabolism and the Nrf2-dependent Ferroptosis Pathway
Northern Jiangsu People's Hospital · NCT05950386
This study is trying to see how long-term lead exposure affects brain cell health and iron levels in workers at a battery factory compared to those who aren't exposed.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Northern Jiangsu People's Hospital (other) |
| Locations | 1 site (Yangzhou, Jiangsu) |
| Trial ID | NCT05950386 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the impact of chronic lead exposure on iron metabolism and the Nrf2-dependent ferroptosis pathway among workers in a lead acid battery factory. It involves comparing blood lead levels and proinflammatory cytokines between exposed workers and a control group. The study utilizes advanced techniques such as atomic absorption spectrometry and quantitative reverse transcription PCR to analyze the effects of lead on neuronal injury and related biological markers. The findings could provide insights into the neurotoxic effects of lead exposure and its mechanisms.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals over 18 years old who have worked in a lead acid battery factory for more than 10 years.
Not a fit: Patients with neurological disorders, endocrine diseases, cancer, or prior exposure to other chemical pollutants may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of lead poisoning's effects on brain health and inform prevention strategies.
How similar studies have performed: While the specific approach of this study may be novel, previous research has indicated that understanding ferroptosis in the context of neurotoxicity is a promising area of investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Aged over 18 years old 2. Work for the lead acid battery factory more than 10 years Exclusion Criteria: 1. Neurological disorders 2. Endocrine diseases 3. Cancer 4. Exposure to any chemical pollutant before
Where this trial is running
Yangzhou, Jiangsu
- Wenjing Zhao — Yangzhou, Jiangsu, China (RECRUITING)
Study contacts
- Study coordinator: Ju Gao
- Email: gaoju_003@163.com
- Phone: +8618118206088
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Lead Poisoning, Neurotoxicity, Ferroptosis, Nrf2, Iron metabolism, Lead exposure