Investigating how ketone drinks affect muscle sugar uptake
The Effect of Ketone Esters on Forearm Glucose Metabolism
This study tests if drinking a ketone supplement can help healthy people’s muscles take in sugar better, which might help with blood sugar control.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 14 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | University of Exeter Academic / other |
| Locations | 1 site (Exeter, Devon) |
| Trial ID | NCT06685913 on ClinicalTrials.gov |
What this trial studies
This research explores the impact of ketone esters on glucose metabolism in healthy individuals. The study aims to determine whether a ketone drink can enhance sugar uptake in skeletal muscles, which is crucial for understanding blood sugar regulation. Participants will receive either a ketone supplement or a placebo to assess the effects on their blood glucose levels. The findings could provide insights into potential treatments for insulin resistance and type 2 diabetes.
Who should consider this trial
Good fit: Ideal candidates are healthy individuals aged 18-40 without any diagnosed metabolic health conditions.
Not a fit: Patients over 40, those with metabolic health conditions, or individuals with allergies to the supplement ingredients may not benefit from this study.
Why it matters
Potential benefit: If successful, this could lead to new dietary strategies for improving blood sugar control and preventing type 2 diabetes.
How similar studies have performed: While the effects of ketones on glucose metabolism have been explored, this specific approach focusing on healthy individuals is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-40 Exclusion Criteria: * Any diagnosed metabolic health condition * Pregnant * Smoker * Diagnosed Cardiovascular disease * Use of medications deemed by research team to affect study outcomes * Recent history of musculoskeletal injury * Aged \>40 or \<18 * Allergy to ingredients in the supplement, including ketones, lactose or milk protein
Where this trial is running
Exeter, Devon
- Nutritional Physiology Research Unit, University of Exeter — Exeter, Devon, United Kingdom (Recruiting)
Study contacts
- Principal investigator: George F Pavis, PhD — University of Exeter
- Study coordinator: George F Pavis, PhD
- Email: g.pavis@exeter.ac.uk
- Phone: +44 01392 725906
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.