Investigating how histamine affects muscle growth after resistance training
Official title: The Role of Histamine in Muscle Protein Synthesis Following Chronic Resistance Training
Run by University Ghent · NCT06152497 · Data updated 2026-11-12
This study is testing whether blocking histamine can help people build more muscle after ten weeks of resistance training.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Men only |
| Enrollment | 50 (estimated) |
| Sponsor | University Ghent Academic / other |
| Locations | 1 site (Ghent, Oost-Vlaanderen) |
| Status | Recruiting |
| Started | September 1, 2023 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | December 13, 2023 |
| Trial ID | NCT06152497 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy males aged 18-45 who are not moderately physically active.
✕Probably not a fit
Patients who smoke, have chronic diseases, high blood pressure, or are resistance trained may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines the role of histamine H1 signaling in muscle protein synthesis following ten weeks of resistance training. Participants will be administered either a placebo or an H1 blocker (Fexofenadine) while engaging in a structured resistance training program. The goal is to understand how histamine influences the body's adaptations to exercise, particularly in skeletal muscle. Insights gained from this research could enhance our understanding of exercise physiology and muscle adaptation mechanisms.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for enhancing muscle growth and recovery in individuals undergoing resistance training.
How similar studies have gone: While the specific role of histamine in resistance training adaptations is less explored, studies on histamine's effects in other exercise contexts suggest potential for novel insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male * 18-45 years * Not to medium physically active Exclusion Criteria: * Smoking * Chronic disease * High blood pressure * Supplement or medication intake * Seasonal allergies * Vegetarian / vegan * Resistance trained
Where it's running
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Department of movement and sports sciences, Ghent University, Belgium
Ghent, Oost-Vlaanderen, Belgium Recruiting
Study contacts
- Principal investigator: Wim Derave, Professor — University Ghent
- Study coordinator: Wim Derave, Professor
- Email: wim.derave@ugent.be
- Phone: 92646326
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.