Investigating how histamine affects muscle growth after resistance training
The Role of Histamine in Muscle Protein Synthesis Following Chronic Resistance Training
NA · University Ghent · NCT06152497
This study is testing whether blocking histamine can help people build more muscle after ten weeks of resistance training.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Male |
| Sponsor | University Ghent (other) |
| Locations | 1 site (Ghent, Oost-Vlaanderen) |
| Trial ID | NCT06152497 on ClinicalTrials.gov |
What this trial studies
This study examines the role of histamine H1 signaling in muscle protein synthesis following ten weeks of resistance training. Participants will be administered either a placebo or an H1 blocker (Fexofenadine) while engaging in a structured resistance training program. The goal is to understand how histamine influences the body's adaptations to exercise, particularly in skeletal muscle. Insights gained from this research could enhance our understanding of exercise physiology and muscle adaptation mechanisms.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy males aged 18-45 who are not moderately physically active.
Not a fit: Patients who smoke, have chronic diseases, high blood pressure, or are resistance trained may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for enhancing muscle growth and recovery in individuals undergoing resistance training.
How similar studies have performed: While the specific role of histamine in resistance training adaptations is less explored, studies on histamine's effects in other exercise contexts suggest potential for novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male * 18-45 years * Not to medium physically active Exclusion Criteria: * Smoking * Chronic disease * High blood pressure * Supplement or medication intake * Seasonal allergies * Vegetarian / vegan * Resistance trained
Where this trial is running
Ghent, Oost-Vlaanderen
- Department of movement and sports sciences, Ghent University, Belgium — Ghent, Oost-Vlaanderen, Belgium (RECRUITING)
Study contacts
- Principal investigator: Wim Derave, Professor — University Ghent
- Study coordinator: Wim Derave, Professor
- Email: wim.derave@ugent.be
- Phone: 92646326
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Histamine