Investigating how histamine affects exercise adaptation
Histamine as a Molecular Transducer of Adaptation to Exercise
This study is testing how histamine affects how our bodies adapt to exercise in young adults aged 18 to 40.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | University of Oregon Academic / other |
| Locations | 1 site (Eugene, Oregon) |
| Trial ID | NCT05206227 on ClinicalTrials.gov |
What this trial studies
This study explores the role of histamine in the body's adaptation to exercise, particularly focusing on its effects on cardiovascular and vascular function. Participants aged 18 to 40 will engage in various exercise interventions or heating sessions to mimic exercise effects. The study will involve inserting an intravenous catheter and microdialysis probes to collect data on histamine release and other physiological responses during these activities. The goal is to better understand the mechanisms behind exercise-induced benefits.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy individuals aged 18 to 40 without significant cardiovascular or metabolic conditions.
Not a fit: Patients with existing cardiovascular diseases, diabetes, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for enhancing cardiovascular health and exercise adaptation in patients.
How similar studies have performed: While the role of histamine in exercise adaptation is a relatively novel area of investigation, previous studies have shown promising results regarding histamine's effects on vascular function.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 -40 Exclusion Criteria: * Systolic ≥ 120 * Diastolic ≥ 80 * Body mass index (BMI) ˃ 28 kg/m2 * Prior diagnosis of cardiovascular disease, diabetes, autonomic disorders, or asthma * Smoking or nicotine use * Ongoing medical therapy (other than birth control) * Ongoing use of over-the-counter or prescription antihistamines * Allergies or hypersensitivities to drugs, local anesthetics, skin disinfectants, adhesives, or latex * Pregnant, breastfeeding subjects, or planning to become pregnant in the next 12 months * Mobility restrictions that interfere with physical activity * High physical activity based on International Physical Activity Questionaire (IPAQ1) * Non-English speaking
Where this trial is running
Eugene, Oregon
- University of Oregon — Eugene, Oregon, United States (Recruiting)
Study contacts
- Principal investigator: John R Halliwill, PhD — University of Oregon
- Study coordinator: John R Halliwill, PhD
- Email: halliwil@uoregon.edu
- Phone: 541-600-4337
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.