Investigating how food intake affects appetite using brain imaging
Physiological Regulation of Energy Intake - The FOOD-PRINT Study Identifying the Hormonal and Neural Footprints of the Visceroceptive, Homeostatic, and Hedonic Components of Food Intake Regulation in Humans
NA · Mayo Clinic · NCT05525845
This study is testing how different types of food and stomach sensations affect appetite by using brain scans on healthy people.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 21 Years to 50 Years |
| Sex | All |
| Sponsor | Mayo Clinic (other) |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT05525845 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the different responses of gut hormones and brain regions to gastric distention, tasteless calories, and palatable food, and how these responses influence appetite regulation. Participants will undergo functional MRI scans while receiving various interventions, including an intragastric balloon and different types of meals. The study focuses on understanding the hedonic and homeostatic mechanisms that govern food intake in healthy individuals.
Who should consider this trial
Good fit: Ideal candidates are healthy adults with a BMI between 18-25 who are weight stable and able to participate in light to moderate physical activity.
Not a fit: Patients with a history of obesity, eating disorders, or significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of appetite regulation, potentially aiding in obesity prevention strategies.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in understanding appetite regulation through brain imaging techniques.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI 18-25 kg/m\^2. * Weight stable for 3 months prior to study entry. * For females: study days will be scheduled during the follicular phase of their menstrual cycle (i.e., the first 13 days (about 2 weeks) of the cycle). * Able to provide written informed consent prior to any study procedures and be willing and able to follow study procedures.. * Ability to perform light to moderate physical activity. Exclusion Criteria: * Any contraindication for MRI scanning. * Any history of childhood (\> 95th percentile) or adult obesity (BMI \>30 kg/m\^2). * Claustrophobia. * High intensity training or physical activity. * Any contraindication for intragastric balloon insertion. * Any allergies to the study meals. * Any history of eating disorder. * Any substance abuse disorder (including alcohol and tobacco). * Any history of psychiatric disorders. * Any cardiovascular, endocrine, pulmonary, neurological, or gastrointestinal comorbidities. * Pregnancy or nursing. * Any history of bariatric surgery or endoscopic bariatric procedure. * Use of any medication or supplement that alters appetite. * Patient has a known history of any condition or factor judged by the investigator to prevent participation in the study or which might hinder study adherence.
Where this trial is running
Rochester, Minnesota
- Mayo Clinic Rochester — Rochester, Minnesota, United States (RECRUITING)
Study contacts
- Principal investigator: Andres Acosta, MD, PhD — Mayo Clinic
- Study coordinator: Megan Schaefer
- Email: RSTINDIVOBESITY@mayo.edu
- Phone: 507-266-6004
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy