Investigating how ectopic fat affects heart attack risk in people living with HIV

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the differences in energy utilization and storage between people living with HIV (PLWHIV) and the general population. Using magnetic resonance imaging (MRI), the study will measure visceral fat around organs such as the heart and liver, which is linked to metabolic syndrome and cardiovascular disease. The research focuses on understanding how factors related to HIV and antiretroviral therapy contribute to increased cardiovascular risk. By identifying these mechanisms, the study seeks to improve risk prediction and management for PLWHIV.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • \>40 years

  * HIV-positive
  * Stable ART for \>6 months with two VL \<40 copies/ml based on local testing protocols
  * CD4 count \>200cells/mm3 for \>2 years from recruitment Inclusion Criteria (all)
  * Understand the study procedures, able to comply with study procedures and voluntarily agree to participate by giving informed written consent

Exclusion Criteria:

* Subjects unable to comply with the study protocol
* History of severe renal impairment (eGFR \<30ml/min)
* History of severe hepatic impairment (Child Pugh Score \>9)
* Active hepatitis B or hepatitis C
* Any active illness, which in the opinion of the investigator precludes participation in the study.
* History of cancer
* Active illicit intravenous drug use
* Investigators may decide the subject cannot proceed if there are any relevant other abnormal results in screening assessments
* History or current GLP-1 agonist use
* For female subjects: pregnancy or breast feeding at screening.
* Subjects currently taking: Atypical antipsychotics, omega 3 supplements, Telmisartan/Irbesartan, Thiazolidinediones or regular NSAID use.
* Familial hypercholesterolaemia

Where it's running

• Royal Liverpool University Hospital
  Liverpool, United Kingdom Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.