Investigating how different fatty acids affect gut microbiota metabolites
Production of Gut Microbiota-Derived Metabolites in Response to Different Fatty Acid Profiles
This study is testing how different types of fats in our diet affect the gut bacteria and their production of certain substances in people with and without obesity and Type 2 diabetes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 45 Years to 65 Years |
| Sex | All |
| Sponsor | Laval University Academic / other |
| Locations | 1 site (Québec, Quebec) |
| Trial ID | NCT05917132 on ClinicalTrials.gov |
What this trial studies
This project aims to explore how the gut microbiota produces metabolites in response to diets rich in either saturated or polyunsaturated fatty acids. It will measure the production of these metabolites over a two-day dietary intervention in individuals with and without obesity and Type 2 diabetes. The study focuses on understanding the role of gut microbiota-derived metabolites, particularly endocannabinoids, in metabolic health. Participants will be monitored for changes in metabolite production following the dietary changes.
Who should consider this trial
Good fit: Ideal candidates are men and women aged 45 to 65 with a BMI between 20 and 35 who are generally healthy and have a moderate diet quality score.
Not a fit: Patients with intestinal pathologies, significant recent weight changes, or those on certain medications or supplements may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new dietary recommendations for improving metabolic health in individuals with obesity and Type 2 diabetes.
How similar studies have performed: While the specific approach of this study may be novel, previous research has shown that dietary interventions can significantly impact gut microbiota and metabolic health.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women aged between 45 and 65 years, menopaused women ; * Body mass index between 20 to 35 kg/m² ; * General good health ; * Score of diet quality (HEI) between 40 and 70 ; * Computer and Internet access ; * Basic understanding of written French ; * Daily stool frequency. Exclusion Criteria: * Intestinal pathologies including inflammatory bowel disease and gastrointestinal cancers ; * Alcohol consumption greater than 15 portions for men and 10 for women weekly. * Active tobacco and cannabis usage ; * Consumption of omega-3 dietary supplements ; * Consumption of dietary supplements (vitamins and probiotics) - must be ceased 2 weeks before the dietary intervention ; * Completion of a course of antibiotics in the past 3 months ; * Important weight change (+/- 5 kg) in the past 6 months ; * Type 1 diabetes or insulin-treated diabetes.
Where this trial is running
Québec, Quebec
- Institut sur la nutrition et les aliments fonctionnels - INAF — Québec, Quebec, Canada (Recruiting)
Study contacts
- Principal investigator: Alain Veilleux, PhD — Laval University
- Study coordinator: Alain Veilleux, PhD
- Email: alain.veilleux@fsaa.ulaval.ca
- Phone: 418 656-3527
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.