Investigating how different agents affect the success of fissure sealants in children's teeth
Official title: Evaluation of the Effect of Different Deproteinizing Agents on the Clinical Success of Fissure Sealants in Permanent Teeth: Splint Mouth Clinical Study
Run by Tokat Gaziosmanpasa University · NCT06988098 · Data updated 2026-11-12
This study is testing different treatments to see which one helps sealants work better on new back teeth in kids aged 6 to 9 to prevent cavities.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Years to 9 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Tokat Gaziosmanpasa University Academic / other |
| Locations | 1 site (Tokat Province) |
| Status | Recruiting |
| Started | August 1, 2024 |
| Main results expected | August 1, 2027 |
| Study ends | August 1, 2027 |
| Registry record updated | May 23, 2025 |
| Trial ID | NCT06988098 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy children aged 6-9 with newly erupted permanent lower first molars who require fissure sealant application.
✕Probably not a fit
Patients with existing fissure sealants, developmental defects, or systemic health issues may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines the impact of various deproteinization agents on the effectiveness of fissure sealants applied to newly erupted permanent lower first molars in children aged 6 to 9. The goal is to determine which agent enhances the clinical success of this non-invasive procedure, aimed at preventing or halting the progression of caries in high-risk tooth surfaces. Participants will be assessed based on specific eligibility criteria, including behavioral assessments and dental health status, to ensure a suitable candidate pool for the intervention.
Why it matters
Potential benefit: If successful, this study could improve the effectiveness of fissure sealants, leading to better prevention of dental caries in children.
How similar studies have gone: While the specific approach of using deproteinization agents in this context may be novel, similar studies have shown that optimizing fissure sealant application can lead to improved dental outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients between the ages of 6-9 who do not have any systemic problems * Have a score of 3 and 4 on the Frankl Behavior Scale * Do not have a habit of clenching and/or grinding their teeth * Have newly erupted permanent lower first molars without caries * Have an indication for fissure sealant application Exclusion Criteria: * Teeth with fissure sealants * Teeth with developmental defects such as hypoplasia * Teeth with approximal or incipient caries lesions on one or both mandibular first permanent molars * Children who are not systemically healthy * Uncooperative children with scores of 1 and 2 on the Frankl Behavior Scale * Children and parents who refuse to attend follow-up appointments * Children with parafunctional habits such as teeth grinding
Where it's running
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Tokat Gaziosmanpaşa University
Tokat Province, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Alem Coşgun
- Email: alemcosgun@hotmail.com
- Phone: +905524133222
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Using deproteinizing agents before fissure sealants on lower primary molars
This trial tests whether applying deproteinizing agents like sodium hypochlorite or hypochlorous acid before placing fissure sealants improves sealant success in healthy children aged 4–6.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.