Investigating how anti-infectives work in critically ill children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to understand the pharmacokinetics and pharmacodynamics of various anti-infectives in critically ill pediatric patients. By analyzing blood samples from children receiving these medications, the study seeks to identify how individual factors affect drug concentrations and clinical outcomes. The goal is to address the significant variability in drug response among critically ill children and to propose more personalized dosing regimens. The study will take place across six pediatric services in public hospitals in Paris, France.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Minor patient requiring the administration of an anti-infective belonging to the following classes : β-lactam antibiotics; aminoglycosides, glycopeptides; fluoroquinolones; other antibiotics (daptomycin, rifampin, trimethoprim, sulfamethoxazole, clarithromycin); fungal; antivirals, during its follow-up or hospitalization

Exclusion Criteria:

* Patient and parents having notified to the doctor that they refuse data recovery.

Where it's running

• Hospital Necker - Enfants Malades (Public Hospitals of Paris)
  Paris, France Recruiting

Study contacts

• Principal investigator: Oualha Mehdi, MD,PhD — Hospital Necker - Enfants Malades
• Study coordinator: Oualha Mehdi, MD,PhD
• Email: mehdi.oualha@nck.aphp.fr
• Phone: +33171196082

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.