Investigating how amino acids affect muscle growth with beta2-adrenergic stimulation.
The Importance of Amino Acid Availability in Modulating the Muscle Anabolic Response to β2-adrenergic Stimulation.
This study is testing how different amino acids can help young, fit people build muscle when combined with a specific medication that stimulates muscle growth.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | University of Copenhagen Academic / other |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT06654986 on ClinicalTrials.gov |
What this trial studies
This project aims to explore the impact of amino acid availability on the muscle anabolic response when stimulated by beta2-adrenergic agents in young, healthy individuals. Participants will be administered either Salmeterol combined with amino acids, Salmeterol with a placebo, or a placebo with a placebo to assess the differences in muscle growth response. The study focuses on physically active men and women aged 18-40 who have a high level of aerobic fitness. By analyzing the effects of these interventions, the research seeks to provide insights into optimizing muscle hypertrophy.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy, physically active men and women aged 18-40 with high aerobic fitness levels.
Not a fit: Patients who are smokers, have chronic illnesses, or are outside the age range may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance strategies for muscle growth and recovery in physically active individuals.
How similar studies have performed: While the specific combination of beta2-adrenergic stimulation and amino acid availability is novel, similar studies have shown promising results in muscle hypertrophy research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-40 * Physically active \>5 hours a week * Maximum oxygen uptake classified as high or very high Exclusion Criteria: * Active smoker currently or within the past 5 years * Regular intake of medication deemed by the responsible study physician to affect the test parameters (hormonal contraception is accepted for women) * Chronic or acute illness deemed by the responsible study physician to affect the test parameters * Deviation from the study protocol * Lean mass index \>21 kg/m² * Pregnancy * Smoker * Blood donation during the past 3 months
Where this trial is running
Copenhagen
- August Krogh Building — Copenhagen, Denmark (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.