Investigating how aging affects protein metabolism in adults
Prandial Metabolic Phenotype in Adults
NA · Texas A&M University · NCT05400733
This study is testing how aging affects how our bodies use protein in older adults and whether different amino acid supplements can improve their metabolism and overall health.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | Texas A&M University (other) |
| Locations | 1 site (College Station, Texas) |
| Trial ID | NCT05400733 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the metabolic changes associated with aging by examining protein turnover in older adults. Using a novel pulse method with stable isotopes, the researchers will measure whole-body metabolism and assess how different amino acid formulations impact metabolic pathways. Participants will undergo a series of assessments, including body composition measurements and functional tests, over several study days while consuming specific nutritional supplements. The goal is to better understand age-related metabolic deterioration and its implications for health.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 60-80 who have stable body weight and can perform basic physical activities independently.
Not a fit: Patients with current malignancies, untreated metabolic diseases, or unstable chronic illnesses are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved nutritional strategies for enhancing protein metabolism in older adults, potentially improving their functional capacity.
How similar studies have performed: While this approach is innovative, previous studies have indicated that understanding metabolic changes in aging can lead to significant insights, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 60-80, inclusive * Stable body-weight (± 5%) for the past 3 months * Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations. * Ability to walk, sit down and stand up independently or with walking mobility aids * Ability to lie in supine or elevated position for up to 7 hours * Willingness and ability to comply with the protocol Exclusion Criteria: * Established diagnosis of current malignancy * History of untreated metabolic diseases including hepatic or renal disorder * Presence of acute illness or metabolically unstable chronic illness * Presence of fever within the last 3 days * Use of short course of oral corticosteroids within 4 weeks preceding study day * (Possible) pregnancy * Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements * Already enrolled in another clinical trial and that clinical trial interferes with participating in this study * Any other condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient
Where this trial is running
College Station, Texas
- Human Clinical Research Facility — College Station, Texas, United States (RECRUITING)
Study contacts
- Study coordinator: Marielle Engelen
- Email: mpkj.engelen@ctral.org
- Phone: 9792202282
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Protein Metabolism, prandial